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. 2022 Feb 16;12(1):2635.
doi: 10.1038/s41598-022-06258-9.

Noninvasive intracranial pressure monitoring in women with migraine

Denise Martineli Rossi  1   2 , Débora Bevilaqua-Grossi  1 , Sérgio Mascarenhas  3 , Hugo Celso Dutra de Souza  1 , Gabriela Ferreira Carvalho  1   4 , Ana Carolina Carmona Vendramim  1 , Stella Vieira Philbois  1 , Fabíola Dach  5 , Francisco José Tallarico  6 , Anamaria Siriani de Oliveira  7
Affiliations

Noninvasive intracranial pressure monitoring in women with migraine

Denise Martineli Rossi et al. Sci Rep. .

Abstract

This cross-sectional study aimed to compare the waveform morphology through noninvasive intracranial pressure (ICP-NI) measurement between patients with migraine and controls, and to analyze the association with clinical variables. Twenty-nine women with migraine, age 32.4 (11.2) years and headache frequency of 12.6 (7.5) days per month and twenty-nine women without headache, age 32.1 (9.0) years, were evaluated. Pain intensity, migraine disability, allodynia, pain catastrophizing, central sensitization and depression were evaluated. The ICP-NI monitoring was performed by a valid method consisting of an extracranial deformation sensor positioned in the patients' scalp, which allowed registration of intracranial pressure waveforms. Heart rate and blood pressure measurements were simultaneously recorded during 20 min in the supine position. The analyzed parameter was the P2/P1 ratio based on mean pulse per minute which P1 represents the percussion wave related to the arterial blood pression maximum and P2 the tidal wave, middle point between the P1 maximum and the dicrotic notch. There was no between-groups difference in the P2/P1 ratio (mean difference: 0.04, IC95%: -0.07 to 0.16, p = 0.352, F (1,1) = 0.881) adjusted by body mass index covariable. The Multiple Linear Regression showed non-statistical significance [F (5,44) = 1.104; p = 0.372; R2 = 0.11)] between the P2/P1 ratio and body mass index, presence of migraine, central sensitization, pain catastrophizing and depression. We found no correlation (p > 0.05) between P2/P1 ratio and migraine frequency, migraine onset, pain intensity, pain intensity at day of examination, disability, allodynia. Migraine patients did not present alterations in the waveform morphology through ICP-NI compared to women without headache and no association with clinical variables was found.

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Conflict of interest statement

The authors declare no competing interests. FJT declares personal fees as employee from Braincare Desenvolvimento e Inovação Tecnológica S.A., during the conduct of the study.

Figures

Figure 1
Figure 1
Illustration of the data collection and the positioning of the extracranial sensor.
Figure 2
Figure 2
Illustration of the data synchronization of heart rate (mV), blood pressure (mmHg) and the ICP-NI measurement (mV).
Figure 3
Figure 3
Illustration from a representative migraine patient. (A) Arterial blood pressure (ABP) and noninvasive intracranial pressure (ICP-NI) from minute seven of data collection. (B,C) Mean pulse of ABP and ICP-NI synchronized data illustrating the arterial blood pression maximum and the dicrotic notch and the P1 and P2 corresponding values and ratio.
See this image and copyright information in PMC

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