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Review
. 2022 Jan 31:12:789311.
doi: 10.3389/fphar.2021.789311. eCollection 2021.

Botanical Drug Extracts Combined With Biomaterial Carriers for Osteoarthritis Cartilage Degeneration Treatment: A Review of 10 Years of Research

Panyun Mu  1 , Jie Feng  1 , Yimei Hu  2 , Feng Xiong  1 , Xu Ma  1 , Linling Tian  1
Affiliations
Review

Botanical Drug Extracts Combined With Biomaterial Carriers for Osteoarthritis Cartilage Degeneration Treatment: A Review of 10 Years of Research

Panyun Mu et al. Front Pharmacol. .

Abstract

Osteoarthritis (OA) is a long-term chronic arthrosis disease which is usually characterized by pain, swelling, joint stiffness, reduced range of motion, and other clinical manifestations and even results in disability in severe cases. The main pathological manifestation of OA is the degeneration of cartilage. However, due to the special physiological structure of the cartilage, once damaged, it is unable to repair itself, which is one of the challenges of treating OA clinically. Abundant studies have reported the application of cartilage tissue engineering in OA cartilage repair. Among them, cell combined with biological carrier implantation has unique advantages. However, cell senescence, death and dedifferentiation are some problems when cultured in vitro. Botanical drug remedies for OA have a long history in many countries in Asia. In fact, botanical drug extracts (BDEs) have great potential in anti-inflammatory, antioxidant, antiaging, and other properties, and many studies have confirmed their effects. BDEs combined with cartilage tissue engineering has attracted increasing attention in recent years. In this review, we will explain in detail how cartilage tissue engineering materials and BDEs play a role in cartilage repair, as well as the current research status.

Keywords: biomaterial carriers; botanical drug; cartilage; extracts; osteoarthritis; tissue engineering.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Experimental flow chart of IA injection of BDEs-loaded biomaterial scaffolds.
FIGURE 2
FIGURE 2
Schematic diagram of chondrocyte regulation of HA-based hydrogel combined with BDEs.
See this image and copyright information in PMC

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References

    1. Abdulbaqi I. M., Darwis Y., Assi R. A., Khan N. A. K. (2018). Transethosomal Gels as Carriers for the Transdermal Delivery of Colchicine: Statistical Optimization, Characterization, and Ex Vivo Evaluation. Drug Des. Devel Ther. 12, 795–813. 10.2147/DDDT.S158018 - DOI - PMC - PubMed
    1. Abed É., Delalandre A., Lajeunesse D. (2017). Beneficial Effect of Resveratrol on Phenotypic Features and Activity of Osteoarthritic Osteoblasts. Arthritis Res. Ther. 19 (1), 151. 10.1186/s13075-017-1365-2 - DOI - PMC - PubMed
    1. Abramson S. B. (2008). Osteoarthritis and Nitric Oxide. Osteoarthritis Cartilage 16 Suppl 2, S15–S20. 10.1016/S1063-4584(08)60008-4 - DOI - PubMed
    1. Aggarwal B. B., Gupta S. C., Sung B. (2013). Curcumin: an Orally Bioavailable Blocker of TNF and Other Pro-inflammatory Biomarkers. Br. J. Pharmacol. 169 (8), 1672–1692. 10.1111/bph.12131 - DOI - PMC - PubMed
    1. Ahmed S., Rahman A., Hasnain A., Lalonde M., Goldberg V. M., Haqqi T. M. (2002). Green tea Polyphenol Epigallocatechin-3-Gallate Inhibits the IL-1 Beta-Induced Activity and Expression of Cyclooxygenase-2 and Nitric Oxide Synthase-2 in Human Chondrocytes. Free Radic. Biol. Med. 33 (8), 1097–1105. 10.1016/s0891-5849(02)01004-3 - DOI - PubMed

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