New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease

doi:10.3389/fphar.2022.813659

Review

. 2022 Jan 31:13:813659.

doi: 10.3389/fphar.2022.813659. eCollection 2022.

New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease

Jing Xu¹, Hao-Ming Xu¹, Mei-Feng Yang², Yu-Jie Liang³, Quan-Zhou Peng⁴, Yuan Zhang⁵, Cheng-Mei Tian⁶, Li-Sheng Wang⁷, Jun Yao⁷, Yu-Qiang Nie¹, De-Feng Li⁷

Affiliations

¹ Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
² Department of Hematology, Yantian District People's Hospital, Shenzhen, China.
³ Shenzhen Kangning Hospital, Shenzhen, China.
⁴ Department of Pathology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.
⁵ Department of Medical Administration, Huizhou Institute of Occupational Diseases Control and Prevention, Huizhou, China.
⁶ Department of Emergency, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.
⁷ Department of Gastroenterology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.

PMID: 35173618
PMCID: PMC8841592
DOI: 10.3389/fphar.2022.813659

Review

New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease

Jing Xu et al. Front Pharmacol. 2022.

. 2022 Jan 31:13:813659.

doi: 10.3389/fphar.2022.813659. eCollection 2022.

Authors

Jing Xu¹, Hao-Ming Xu¹, Mei-Feng Yang², Yu-Jie Liang³, Quan-Zhou Peng⁴, Yuan Zhang⁵, Cheng-Mei Tian⁶, Li-Sheng Wang⁷, Jun Yao⁷, Yu-Qiang Nie¹, De-Feng Li⁷

Affiliations

¹ Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
² Department of Hematology, Yantian District People's Hospital, Shenzhen, China.
³ Shenzhen Kangning Hospital, Shenzhen, China.
⁴ Department of Pathology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.
⁵ Department of Medical Administration, Huizhou Institute of Occupational Diseases Control and Prevention, Huizhou, China.
⁶ Department of Emergency, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.
⁷ Department of Gastroenterology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.

PMID: 35173618
PMCID: PMC8841592
DOI: 10.3389/fphar.2022.813659

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa. Environmental factors, genetics, intestinal microbiota, and the immune system are all involved in the pathophysiology of IBD. Lately, accumulating evidence has shown that abnormal epigenetic changes in DNA methylation, histone markers, and non-coding RNA expression greatly contribute to the development of the entire disease. Epigenetics regulates many functions, such as maintaining the homeostasis of the intestinal epithelium and regulating the immune system of the immune cells. In the present study, we systematically summarized the latest advances in epigenetic modification of IBD and how epigenetics reveals new mechanisms of IBD. Our present review provided new insights into the pathophysiology of IBD. Moreover, exploring the patterns of DNA methylation and histone modification through epigenetics can not only be used as biomarkers of IBD but also as a new target for therapeutic intervention in IBD patients.

Keywords: DNA methylation; epigenetics; histone modifications; inflammatory; inflammatory bowel disease; miRNA.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

**FIGURE 1**
The diagram shows different factors of epigenetics in IBD.

**FIGURE 2**
The epigenetic machinery consists of DNA methylation, histone modifications short interfering RNA were participated the regulation of inflammatory bowel disease.

**FIGURE 3**
The differently expressed DNA methylation compared UC samples with normal samples.

**FIGURE 4**
The role of microRNAs in epigenetic regulation in inflammatory bowel disease. The upregulated microRNA in inflammatory bowel disease tissue and peripheral blood. miRNA also mediated the interaction of microbiota microbiome, immune cells and host cells in IBD.

See this image and copyright information in PMC

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References

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1. Adams A. T., Kennedy N. A., Hansen R., Ventham N. T., OʼLeary K. R., Drummond H. E., et al. Two-stage Genome-wide Methylation Profiling in Childhood-Onset Crohn's Disease Implicates Epigenetic Alterations at the VMP1/MIR21 and HLA Loci. Inflamm. Bowel Dis. 2014;20:1784–1793.10.1097/MIB.0000000000000179 - DOI - PMC - PubMed
1. Alam K. J., Mo J. S., Han S. H., Park W. C., Kim H. S., Yun K. J., et al. MicroRNA 375 Regulates Proliferation and Migration of colon Cancer Cells by Suppressing the CTGF-EGFR Signaling Pathway. Int. J. Cancer 2017;141:1614–1629.10.1002/ijc.30861 - DOI - PubMed
1. Arasaradnam R. P., Commane D. M., Bradburn D., Mathers J. C. A Review of Dietary Factors and its Influence on DNA Methylation in Colorectal Carcinogenesis. Epigenetics 2008;3:193–198.10.4161/epi.3.4.6508 - DOI - PubMed
1. Arasaradnam R. P., Khoo K., Bradburn M., Mathers J. C., Kelly S. B. DNA Methylation of ESR-1 and N-33 in Colorectal Mucosa of Patients with Ulcerative Colitis (UC). Epigenetics 2010;5:422–426.10.4161/epi.5.5.11959 - DOI - PubMed

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[1] Aalto A. P., Pasquinelli A. E. Small Non-coding RNAs Mount a Silent Revolution in Gene Expression. Curr. Opin. Cell Biol 2012;24:333–340.10.1016/j.ceb.2012.03.006 - DOI - PMC - PubMed

[2] Aalto A. P., Pasquinelli A. E. Small Non-coding RNAs Mount a Silent Revolution in Gene Expression. Curr. Opin. Cell Biol 2012;24:333–340.10.1016/j.ceb.2012.03.006 - DOI - PMC - PubMed

[3] Adams A. T., Kennedy N. A., Hansen R., Ventham N. T., OʼLeary K. R., Drummond H. E., et al. Two-stage Genome-wide Methylation Profiling in Childhood-Onset Crohn's Disease Implicates Epigenetic Alterations at the VMP1/MIR21 and HLA Loci. Inflamm. Bowel Dis. 2014;20:1784–1793.10.1097/MIB.0000000000000179 - DOI - PMC - PubMed

[4] Adams A. T., Kennedy N. A., Hansen R., Ventham N. T., OʼLeary K. R., Drummond H. E., et al. Two-stage Genome-wide Methylation Profiling in Childhood-Onset Crohn's Disease Implicates Epigenetic Alterations at the VMP1/MIR21 and HLA Loci. Inflamm. Bowel Dis. 2014;20:1784–1793.10.1097/MIB.0000000000000179 - DOI - PMC - PubMed

[5] Alam K. J., Mo J. S., Han S. H., Park W. C., Kim H. S., Yun K. J., et al. MicroRNA 375 Regulates Proliferation and Migration of colon Cancer Cells by Suppressing the CTGF-EGFR Signaling Pathway. Int. J. Cancer 2017;141:1614–1629.10.1002/ijc.30861 - DOI - PubMed

[6] Alam K. J., Mo J. S., Han S. H., Park W. C., Kim H. S., Yun K. J., et al. MicroRNA 375 Regulates Proliferation and Migration of colon Cancer Cells by Suppressing the CTGF-EGFR Signaling Pathway. Int. J. Cancer 2017;141:1614–1629.10.1002/ijc.30861 - DOI - PubMed

[7] Arasaradnam R. P., Commane D. M., Bradburn D., Mathers J. C. A Review of Dietary Factors and its Influence on DNA Methylation in Colorectal Carcinogenesis. Epigenetics 2008;3:193–198.10.4161/epi.3.4.6508 - DOI - PubMed

[8] Arasaradnam R. P., Commane D. M., Bradburn D., Mathers J. C. A Review of Dietary Factors and its Influence on DNA Methylation in Colorectal Carcinogenesis. Epigenetics 2008;3:193–198.10.4161/epi.3.4.6508 - DOI - PubMed

[9] Arasaradnam R. P., Khoo K., Bradburn M., Mathers J. C., Kelly S. B. DNA Methylation of ESR-1 and N-33 in Colorectal Mucosa of Patients with Ulcerative Colitis (UC). Epigenetics 2010;5:422–426.10.4161/epi.5.5.11959 - DOI - PubMed

[10] Arasaradnam R. P., Khoo K., Bradburn M., Mathers J. C., Kelly S. B. DNA Methylation of ESR-1 and N-33 in Colorectal Mucosa of Patients with Ulcerative Colitis (UC). Epigenetics 2010;5:422–426.10.4161/epi.5.5.11959 - DOI - PubMed

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New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease

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New Insights Into the Epigenetic Regulation of Inflammatory Bowel Disease

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Abstract

Conflict of interest statement

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Abstract

Conflict of interest statement

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