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Review
. 2022 Jan 31:13:824907.
doi: 10.3389/fphar.2022.824907. eCollection 2022.

Neuroinflammation and Neutrophils: Modulation by Ouabain

Jacqueline Alves Leite  1 , Luiz Henrique Agra Cavalcante-Silva  2 , Martina Raissa Ribeiro  3 , Geovanni de Morais Lima  3 , Cristoforo Scavone  3 , Sandra Rodrigues-Mascarenhas  2
Affiliations
Review

Neuroinflammation and Neutrophils: Modulation by Ouabain

Jacqueline Alves Leite et al. Front Pharmacol. .

Abstract

Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na+/K+-ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion balance. These steroids are known to modulate some immune responses, including cytokine production, neutrophil migration, and inflammation (peripherally and in the nervous system). Inflammation can occur in response to homeostasis perturbations and is related to the development of many diseases, including immune-mediated diseases and neurodegenerative disorders. Considering the neutrophils role in the general neuroinflammatory response and that these cells can be modulated by cardiac steroids, this work aims to review the possible regulation of neutrophilic neuroinflammation by the cardiac steroid ouabain.

Keywords: inflammation; innate immunity; neuroimmune interactions; neuropharmacology; ouabain.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Effect of ouabain on neutrophils in peripheral and neuroinflammation. (A) In neuroinflammation ouabain can reduces NF-κB and iNOS activation and inflammatory cytokines (IL-1), however, the effects of this steroid in neutrophils remains to be elucidated. (B) Impairment of neutrophil migration caused by ouabain may involve reduction of adhesion molecule CD18, P-p38 MAPK, and decrease of inflammatory cytokines. Created with BioRender.com.
See this image and copyright information in PMC

References

    1. Akira S., Uematsu S., Takeuchi O. (2006). Pathogen Recognition and Innate Immunity. Cell 124, 783–801. 10.1016/J.CELL.2006.02.015 - DOI - PubMed
    1. Alpert J. S. (2021). Is Digitalis Therapy Still Viable? Foxglove Therapy Makes a Comeback. Am. J. Med. 134, 1–2. 10.1016/J.AMJMED.2020.09.001 - DOI - PubMed
    1. Bagrov A. Y., Shapiro J. I., Fedorova O. V. (2009). Endogenous Cardiotonic Steroids: Physiology, Pharmacology, and Novel Therapeutic Targets. Pharmacol. Rev. 61, 9–38. 10.1124/pr.108.000711 - DOI - PMC - PubMed
    1. Bautista-Becerril B., Campi-Caballero R., Sevilla-Fuentes S., Hernández-Regino L. M., Hanono A., Flores-Bustamante A., et al. (2021). Immunothrombosis in Covid-19: Implications of Neutrophil Extracellular Traps. Biomolecules 11. 694. 10.3390/biom11050694 - DOI - PMC - PubMed
    1. Blanco G., Mercer R. W. (1998). Isozymes of the Na-K-ATPase: Heterogeneity in Structure, Diversity in Function. Am. J. Physiol. 275, F633–F650. 10.1152/AJPRENAL.1998.275.5.F633 - DOI - PubMed

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