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. 2022 Jan 31:12:807974.
doi: 10.3389/fpsyt.2021.807974. eCollection 2021.

Symptom Clusters and Quality of Life in Cervical Cancer Patients Receiving Concurrent Chemoradiotherapy: The Mediating Role of Illness Perceptions

Lan Zhang  1   2   3 , Jia Wang  1   2 , Tangzhen Chen  1   2 , Min Tian  1   2 , Qimin Zhou  1   2 , Jianhua Ren  1   2
Affiliations

Symptom Clusters and Quality of Life in Cervical Cancer Patients Receiving Concurrent Chemoradiotherapy: The Mediating Role of Illness Perceptions

Lan Zhang et al. Front Psychiatry. .

Abstract

Objectives: Although studies shows that symptom clusters and illness perceptions are negatively associated with quality of life (QoL), it is unclear how these variables of cervical cancer patients who receive concurrent chemoradiotherapy (CCRT) relate to each other. This study aimed to identify the symptom clusters in cervical cancer patients who receive CCRT and evaluate the mediating effect of illness perceptions on the relationship between symptom clusters and QoL.

Methods: A cross-sectional survey was conducted on 286 cervical cancer patients receiving CCRT from October 2019 to October 2020. M.D. Anderson Symptom Inventory, Brief Illness Perception Questionnaire, and Functional Assessment Cancer Therapy-Cervix were applied to investigate the symptom clusters, illness perceptions and QoL of the participants, respectively. Exploratory factor analysis was conducted to identify symptom clusters. The relationships among symptom clusters, illness perceptions, and QoL were analyzed with the structural equation modeling.

Results: A total of four symptom clusters were identified, including psychological status symptom cluster, therapy side-effect symptom cluster, sickness symptom cluster, and gastrointestinal symptom cluster (χ2 = 1,552.282, Df = 78, P < 0.001). Symptom clusters, illness perceptions, and QoL were significantly correlated. Symptom clusters had significant direct (β = -0.38, P < 0.001) and indirect effects (β = -0.21, P < 0.001) on QoL.

Conclusion: Illness perceptions played a significant mediating role between symptom clusters and QoL in cervical cancer patients receiving CCRT. Strategies like prompting effective symptom management for the purposes of alleviating illness perceptions may contribute to improving their QoL.

Keywords: cervical cancer; illness perceptions; mediating role; quality of life; symptom clusters.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Final structural model. The Standardized path coefficients are presented for each pathway. χ2: Chi-square; df, degrees of freedom; GFI, goodness-of-fit index; AGFI, adjusted goodness-of-fit index; TLI, Tucker–Lewis Index; CFI, comparative fit index; RMSEA, root mean square error of approximation; e, error.
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. (2018) 68:394–424. 10.3322/caac.21492 - DOI - PubMed
    1. Arbyn M, Weiderpass E, Bruni L, de Sanjose S, Saraiya M, Ferlay J, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Global Health. (2020) 8:E191–203. 10.1016/S2214-109X(19)30482-6 - DOI - PMC - PubMed
    1. Potter R, Tanderup K, Kirisits C, de Leeuw A, Kirchheiner K, Nout R, et al. The EMBRACE II study: the outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies. Clin Transl Radiat Oncol. (2018) 9:48–60. 10.1016/j.ctro.2018.01.001 - DOI - PMC - PubMed
    1. Thapa N, Maharjan M, Xiong Y, Jiang D, Thi-Phuong N, Petrini MA, et al. Impact of cervical cancer on quality of life of women in Hubei, China. Sci Rep. (2018) 8:11993. 10.1038/s41598-018-30506-6 - DOI - PMC - PubMed
    1. Koh W-J, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, et al. Cervical cancer, version 3.2019. J Natl Compr Canc Netw. (2019) 17:64–84. 10.6004/jnccn.2019.0001 - DOI - PubMed