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. 2022 Jan 31:12:765463.
doi: 10.3389/fneur.2021.765463. eCollection 2021.

A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure - A Theoretical Approach Using Fluid Dynamics

Masashi Kameyama  1 , Toshimitsu Momose  2 , Kenji Ishibashi  3 , Kenji Ishii  3
Affiliations

A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure - A Theoretical Approach Using Fluid Dynamics

Masashi Kameyama et al. Front Neurol. .

Abstract

Cerebral blood flow (CBF) / cerebral blood volume (CBV) ratio derived by [15O] H2O/ CO2 and CO positron emission tomography (PET) examination has been used as an index for cerebral perfusion pressure (CPP). CBF/CBV was demonstrated to be related mean arterial pressure (MAP) in baboons. However, this formula has not been confirmed to be proportionate to CPP. We have developed a new index for CPP using the Poiseuille equation based on a simple model. Our model suggests that CBF/CBV2 is proportionate to CPP and that it is mathematically a more accurate index than CBF/CBV. This new index needs experimental validation in the future.

Keywords: cerebral blood flow (CBF); cerebral blood volume (CBV); cerebral perfusion pressure (CPP); fluid mechanics; positron emission tomography (PET).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Model of a region of brain. The region contains one vessel. The vessel supplies blood flow to the entire region.
Figure 2
Figure 2
A simulation of CBF/CBV and CBF/CBV2.
Figure 3
Figure 3
Relationship between mean arterial blood pressure (MAP) and CBF/CBV (A), between MAP and CBF/CBV2 (B).
Figure 4
Figure 4
Example of15O PET study.
See this image and copyright information in PMC

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