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. 2022 Jan 15;14(1):594-602.
eCollection 2022.

Effect of various doses of rosuvastatin in the treatment of elderly patients with unstable angina pectoris

Jingyun Fang  1 , Xueli Zhang  2
Affiliations

Effect of various doses of rosuvastatin in the treatment of elderly patients with unstable angina pectoris

Jingyun Fang et al. Am J Transl Res. .

Abstract

Objectives: This prospective study aimed to explore the effects of various doses of rosuvastatin on the hemodynamic changes, highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels in elderly patients with unstable angina pectoris.

Methods: One-hundred and six elderly patients with unstable angina pectoris were enrolled and divided into group A (n=55) and group B (n=51). Under the same treatment for angina pectoris, patients in groups A and B were administered with 5 mg and 10 mg of rosuvastatin orally once every night, respectively. The two groups were compared in terms of hemorheology, coagulation indices and immune reaction (serum hs-CRP and IL-6 levels), changes of clinical indices, electrocardiograph (ECG), therapeutic effect, and incidence of adverse reactions. Serum hs-CRP and IL-6 levels were detected by ELISA method, and their correlation was analyzed by Pearson method.

Results: Whole blood viscosity at high cut (BVH), whole blood viscosity at low cut (BVL), plasma viscosity (PV), and erythrocyte sedimentation rate (ESR), immunoglobulin index, and the hs-CRP and IL-6 levels decreased in both groups after treatment and were lower in group B than in group A (P<0.05). Prothrombin time (PT) and activated partial thromboplastin time (APTT) increased, while fibrinogen (FIB) decreased in both groups after treatment (P<0.05). Group B was superior to group A in the onset times of myocardial ischemia and angina pectoris, the total duration of myocardial ischemia, and the total effective rate indicated by ECG (P<0.05). No statistical difference was observed in the incidence of adverse reactions between the two groups after treatment (P>0.05).

Conclusions: The optimal efficacy of rosuvastatin at 10 mg/day was higher than that of rosuvastatin at 5 mg/day.

Keywords: IL-6; Various doses; elderly patients; hs-CRP; rosuvastatin; unstable angina pectoris.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of changes in hemorheology before and after treatment between the two groups. After treatment, both groups achieved reductions in BVL (A), BVH (B), PV (C), and ESR (D), which were more significant in group B than in group A. Note: *represents P<0.05.
Figure 2
Figure 2
Comparison of changes in coagulation indices before and after treatment between the two groups. After treatment, both groups achieved elevations in PT (A) and APTT (B), and decrease in FIB (C), which were more significant in group B than in group A. Note: *represents P<0.05.
Figure 3
Figure 3
Comparison of changes in immune reaction before and after treatment between the two groups. After treatment, both groups achieved reductions in IgG (A), IgA (B), and IgM (C), which were more significant in group B than in group A. Note: *represents P<0.05.
Figure 4
Figure 4
Comparison of serum hs-CRP and IL-6 levels before and after treatment between the two groups. After treatment, both groups achieved reductions in hs-CRP (A) and IL-6 (B), which were more significant in group B than in group A. Note: *represents P<0.05.
Figure 5
Figure 5
Analysis on the correlation between the hs-CRP and IL-6 levels in elderly patients with unstable angina pectoris. Pearson analysis demonstrated a positive correlation between the hs-CRP and IL-6 levels in elderly patients with unstable angina pectoris (r=0.649, P<0.001).
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References

    1. Tresukosol D, Sriyudhasak O, Panchavinnin P, Phankingthongkum R. Nadroparin and percutaneous transluminal coronary angioplasty in elderly thais with unstable angina. Applied Catalysis A General. 2005;159:241–258.
    1. Hong MK. S22-1 comparison of coronary plaque rupture between stable angina and acute myocardial infarction: a three-vessel intravascular ultrasound study in 235 patients. CVD Prevention and Control. 2009:S33–S34. - PubMed
    1. Mintz GS, Maehara A, Bui AB, Weissman NJ. Multiple versus single coronary plaque ruptures detected by intravascular ultrasound in stable and unstable angina pectoris and in acute myocardial infarction. Am J Cardiol. 2003;91:1333. - PubMed
    1. Pelter MM, Loranger DL, Kozik TM, Kedia A, Ganchan RP, Ganchan D, Hu X, Carey MG. Among unstable angina and non-ST-elevation myocardial infarction patients, transient myocardial ischemia and early invasive treatment are predictors of major in-hospital complications. J Cardiovasc Nurs. 2016;31:E10–19. - PMC - PubMed
    1. Han X, Jeong MH, Sim DS, Kim MC, Kim Y, Kim JH, Hong YJ, Ahn Y. Successful treatment of coronary spasm with atherosclerosis rapidly progressing to acute myocardial infarction in a young woman. J Lipid Atheroscler. 2018;7:68–75.

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