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. 2022;4(1):170.
doi: 10.47363/jmhc/2022(4)179. Epub 2022 Jan 28.

An Analysis of Peripheral Neuropathy Symptom Characteristics in HIV

Joyce K Anastasi  1 , Bernadette Capili  2 , Donald J McMahon  3
Affiliations

An Analysis of Peripheral Neuropathy Symptom Characteristics in HIV

Joyce K Anastasi et al. J Med Healthc. 2022.

Abstract

Objectives: A gap remains in understanding the association among the symptoms of distal sensory peripheral neuropathy (DSPN) (pain, aching, burning, pins and needles, numbness), comorbidities, and medication use among persons living with People Living with HIV/AIDS (PLWH) with DSPN. This report describes the symptom characteristics associated with prescribed treatment regimens (HIV and non-HIV medications) and comorbidities from a cohort of PLWH experiencing symptoms of DSPN who reside in New York City.

Methods: Our sample (n=353) included PLWH who were 18 years or older, and with painful lower limb (LL) peripheral neuropathy screened for an ongoing clinical trial to reduce DSPN symptoms using acupuncture/moxibustion. The trial participants completed a screening interview where they reported age, gender, race, ethnicity, HIV status, presence of LL DSPN and DSPN symptoms, current medications, and comorbidities.

Results: Of 465 persons screened, 353 provided information for inclusion in this analysis. Seventy-eight percent rated their LL DSPN in the "severe" or "very severe" discomfort/pain range. Nearly half of those were taking prescribed or over-the-counter medication, such as nonnarcotic analgesics, antidepressants, and anticonvulsants, to manage their DSPN discomfort/pain. Despite the use of OTC and or prescription pain relievers, participants reported insufficient symptom relief.

Discussion: Combination Antiretroviral Therapies (CART) effectively control viral load and maintain healthy T-cell levels in individuals with HIV. It has made HIV a chronic disease for many. However, HIV DPSN remains prevalent and has a negative impact on the lives of PLWH. Our findings highlight that, despite the availability and the use of CART, DSPN remains prevalent and not well managed. A critical need exists for the development of effective interventions to manage DSPN symptoms.

Keywords: Distal Sensory Peripheral Neuropathy; HIV; Neuropathy; Pain; Symptom Characteristics; Symptom Science.

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Conflict of interest statement

Conflicts of Interest: “The authors declare no conflict of interest.”

References

    1. Anastasi JK, Pakhomova AM (2020) Assessment and Management of HIV Distal Sensory Peripheral Neuropathy: Understanding the Symptoms. The Journal for Nurse Practitioners 16: 276–280. - PMC - PubMed
    1. Neuropathy, FFfP (2020) Symptoms of Peripheral Neuropathy. Available from: https://www.foundationforpn.org/symptoms/.
    1. Arenas-Pinto A, Thompson Jennifer, Musoro Godfrey, Musana Hellen, Lugemwa Abbas et al. (2016) Peripheral neuropathy in HIV patients in sub-Saharan Africa failing first-line therapy and the response to second-line ART in the EARNEST trial. J Neurovirol 22: 104–113. - PubMed
    1. Aware P (2020) Positively Awared Drug Guides. Available from: https://www.positivelyaware.com/2021-hiv-drug-guide.
    1. Schutz SR-P (2013) J HIV-related neuropathy: Current perspectives. HIV/AIDS - Research and Palliative Care 5: 243–251. - PMC - PubMed

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