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. 2022 May;72(5):1018-1025.
doi: 10.1007/s12031-022-01979-y. Epub 2022 Feb 16.

Neuromodulatory Mechanisms of a Memory Loss-Preventive Effect of Alpha-Lipoic Acid in an Experimental Rat Model of Dementia

Hristian Staykov  1 , Maria Lazarova  2 , Yozljam Hassanova  3 , Miroslava Stefanova  3 , Lyubka Tancheva  3 , Rumen Nikolov  1
Affiliations

Neuromodulatory Mechanisms of a Memory Loss-Preventive Effect of Alpha-Lipoic Acid in an Experimental Rat Model of Dementia

Hristian Staykov et al. J Mol Neurosci. 2022 May.

Abstract

This study evaluates some of the neuromodulatory mechanisms of the memory loss preventive effect of alpha-lipoic acid (ALA) in a scopolamine (Sco)-induced rat model of Alzheimer's disease (AD) type dementia. Our results confirmed that Sco administration induces significant memory impairment, worsens exploratory behaviour and habituation, increases acetylcholinesterase (AChE) activity, and induces pathological monoamine content changes in the prefrontal cortex and hippocampus. ALA administration largely prevented Sco-induced memory impairment. It also improved exploratory behaviour and preserved habituation, and it decreased AChE activity, reversing it to control group levels, and corrected aberrant monoamine levels in the prefrontal cortex and hippocampus. According to the data available, this is the first time that ALA-induced changes in AChE and monoamine levels in the prefrontal cortex and hippocampus (brain structures related to learning and memory) have been demonstrated in a Sco-induced rat model of AD type dementia.

Keywords: Acetylcholine esterase; Alzheimer’s type dementia; Lipoic acid; Memory loss; Monoamine; Neurodegeneration.

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