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. 2022 May;44(5):1069-1078.
doi: 10.1002/hed.27002. Epub 2022 Feb 17.

Development of second primary malignancies after transoral surgery in human papilloma virus-positive oropharyngeal squamous cell carcinoma

Katelyn Stepan  1 , Ethan Craig  2 , Scott Andrew Skillington  2 , Brian C Deutsch  2 , Stephanie Chen  2 , Nneoma S Wamkpah  2 , Craig A Bollig  3 , Dorina Kallogjeri  2 , Wade L Thorstad  4 , Sidharth V Puram  2 , Patrik Pipkorn  2 , Ryan S Jackson  2
Affiliations

Development of second primary malignancies after transoral surgery in human papilloma virus-positive oropharyngeal squamous cell carcinoma

Katelyn Stepan et al. Head Neck. 2022 May.

Abstract

Background: Little data exists regarding the incidence of oropharyngeal and upper aerodigestive tract (UADT) second primary malignancies (SPM) among human papilloma virus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC). Here we evaluate SPM rates among patients with HPV-related OPSCC.

Methods: A retrospective cohort study of 412 patients with HPV-related OPSCC who underwent transoral resection +/- adjuvant therapy at a single center between 1996 and 2018.

Results: Twenty patients (4.9%) developed SPM of the UADT, nine (2.2%) occurring in the oropharynx. Median time to diagnosis was 59.5 months (0-173 months). Risk of SPM was lower for patients receiving adjuvant radiation (aHR: 0.25, 95%CI: 0.08-0.78). There was no difference in overall or disease-free survival between those with and without SPM.

Conclusion: The rate of SPM among patients with HPV-positive OPSCC is lower than reported rates among HPV-negative OPSCC. To date, this is the largest study evaluating SPM in patients with surgically treated HPV-positive OPSCC.

Keywords: HPV; oropharynx; second primary; squamous cell carcinoma; transoral surgery.

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There are no conflicts of interest or financial disclosures.

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