Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 17;17(2):e0262318.
doi: 10.1371/journal.pone.0262318. eCollection 2022.

Treatment outcomes of patients with MDR-TB and its determinants at referral hospitals in Ethiopia

Mengistu K Wakjira  1 , Peter T Sandy  2 , A H Mavhandu-Mudzusi  3
Affiliations

Treatment outcomes of patients with MDR-TB and its determinants at referral hospitals in Ethiopia

Mengistu K Wakjira et al. PLoS One. .

Abstract

Background: There is limited empirical evidence in Ethiopia on the determinants of treatment outcomes of patients with multidrug-resistant tuberculosis (MDR-TB) who were enrolled to second-line anti-tuberculosis drugs. Thus, this study investigated the determinants of treatment outcomes in patients with MDR-TB at referral hospitals in Ethiopia.

Design and methods: This study was underpinned by a cross-sectional quantitative research design that guided both data collection and analysis. Data is collected using structured questionnaire and data analyses was performed using the Statistical Package for Social Sciences. Multi-variable logistic regression was used to control for confounders in determining the association between treatment outcomes of patients with MDR-TB and selected predictor variables, such as co-morbidity with MDR-TB and body mass index.

Results: From the total of 136 patients with MDR-TB included in this study, 31% had some co-morbidity with MDR-TB at baseline, and 64% of the patients had a body mass index of less than 18.5 kg/m2. At 24 months after commencing treatment, 76 (69%), n = 110), of the patients had successfully completed treatment, while 30 (27%) died of the disease. The odds of death was significantly higher among patients with low body mass index (AOR = 2.734, 95% CI: 1.01-7.395; P<0.048) and those with some co-morbidity at baseline (AOR = 4.260, 95%CI: 1.607-11.29; p<0.004).

Conclusion: The higher proportion of mortality among patients treated for MDR-TB at Adama and Nekemte Hospitals, central Ethiopia, is attributable to co-morbidities with MDR-TB, including HIV/AIDS and malnutrition. Improving socio-economic and nutritional support and provision of integrated care for MDR-TB and HIV/AIDS is recommended to mitigate the higher level of death among patients treated for MDR-TB.

PubMed Disclaimer

Conflict of interest statement

During the time the research was conducted MKW was employed to Abt Associates Inc. operating in Ethiopia. There are no patents, products in development or marketed products associated with this research to declare. But the authors hereby confirm that this does not alter our adherence to PLOSONE policies on sharing data and materials.

References

    1. Heemskerk D, Caws M, Marais B & Farrar J. Tuberculosis in adults and children. New York: Springer; 2015. - PubMed
    1. Zwerling A, Hanrahan C & Dowdy DW. Ancient disease, modern epidemiology: a century of progress in understanding and fighting tuberculosis. Am J Epidemiol. 2016; 183 (5):407–414. doi: 10.1093/aje/kwv176 - DOI - PubMed
    1. Davies PDO, Gordon SB & Davies G, editors. Clinical tuberculosis. 5th edition. London: CRC Press; 2014.
    1. Ribon W, editor. Tuberculosis: expanding knowledge. Published by AvE4EvA. E-ISBN-13:978–953-51-2139-8; 2015.
    1. Munsab A, Santanu M, Revinder M, Pradeep K & Ankur G. Effect of social factors on tuberculosis patients: a comprehensive illness behavior study. IJRAP. 2013; 3(1):123–126.

Publication types

Substances