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Comment
. 2022 Mar 14;40(3):243-245.
doi: 10.1016/j.ccell.2022.02.004. Epub 2022 Feb 16.

Stem-cell-like T cells have a specific entry gate to the tumor

Werner Held  1 , Sanjiv A Luther  2 , Tatiana V Petrova  3
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Stem-cell-like T cells have a specific entry gate to the tumor

Werner Held et al. Cancer Cell. .
Free article

Abstract

Tumor-infiltrated T cells with stem-cell-like properties are important for determining the immunotherapy response. In this issue of Cancer Cell, Asrir and colleagues show that their entry requires specialized tumor-associated endothelial cells that resemble immature and inflamed lymph node vessels and that immunotherapy enhances the recruitment capacity of these endothelial cells.

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Conflict of interest statement

Declaration of interests T.V.P. receives research support from Roche. The remaining authors declare no competing interests.

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