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. 2023 Apr;21(4):1097-1099.e3.
doi: 10.1016/j.cgh.2022.02.020. Epub 2022 Feb 14.

Diverticulosis Is Associated With Internal Hemorrhoids on Colonoscopy: Possible Clues to Etiology

Jared A Sninsky  1 , Joseph Galanko  2 , Robert S Sandler  2 , Anne F Peery  2
Affiliations

Diverticulosis Is Associated With Internal Hemorrhoids on Colonoscopy: Possible Clues to Etiology

Jared A Sninsky et al. Clin Gastroenterol Hepatol. 2023 Apr.

Abstract

Hemorrhoids are a common but poorly understood gastrointestinal condition.1 Bowel habits and fiber consumption are frequently cited as risk factors for hemorrhoids, but research has been inconclusive.2 Recent genome-wide association studies (GWAS) have suggested an association between diverticular disease and hemorrhoids.3 We sought to investigate the association between colonic diverticulosis and internal hemorrhoids to validate the prediction from the GWAS.

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Conflict of interest statement

Conflict of Interest: None of the authors have financial, professional, or personal conflicts of interest.

Comment in

  • Diverticulosis and Hemorrhoids: Fact or Artefact?
    Fathallah N, Spindler L, De Parades V. Fathallah N, et al. Clin Gastroenterol Hepatol. 2023 Dec;21(13):3461. doi: 10.1016/j.cgh.2023.03.038. Epub 2023 Apr 7. Clin Gastroenterol Hepatol. 2023. PMID: 37031714 No abstract available.

References

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    1. Sandler RS, Peery AF. Rethinking What We Know About Hemorrhoids. Clin Gastroenterol Hepatol 2019;17:8–15. - PMC - PubMed
    1. Zheng T, Ellinghaus D, Juzenas S, et al. Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease. Gut 2021;70:1538. - PMC - PubMed
    1. Schafmayer C, Harrison JW, Buch S, et al. Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut 2019;68:854–65. - PubMed

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