Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Feb 18;16(1):71.
doi: 10.1186/s13256-022-03284-z.

Aggressive (deep) angiomyxoma of the vulva: a case report

Lajya Devi Goyal #  1 , Priyanka Garg #  2 , Rama Badyal  3 , Shivali Bhalla  4
Affiliations
Case Reports

Aggressive (deep) angiomyxoma of the vulva: a case report

Lajya Devi Goyal et al. J Med Case Rep. .

Abstract

Background: Aggressive angiomyxoma of the vulva is a benign, slow-growing tumor originating from myxoid cells of connective tissue. The tumor is known for multiple local recurrences with a low tendency to metastasize. Only around 350 cases have been documented in the scientific literature so far.

Case presentation: We report a case of a 40-year-old North Indian, unmarried woman with a swelling on the left labium majora for 7 years, along with surface ulceration over the mass. Local examination showed a well-circumscribed, 8 × 8 cm pedunculated mass arising from the left labium majora with an overlying ulcer measuring 6 cm × 4 cm. After taking informed written consent, wide local excision of the mass and surrounding margins was done under anesthesia. Histopathology was suggestive of aggressive angiomyxoma. Immunohistochemistry was done, which was positive for estrogen and progesterone receptors. Her postoperative recovery was uneventful. The patient was given three doses of gonadotropin-releasing hormone agonist (injection, leuprolide 3.75 mg) once a month. No recurrence has been reported so far on follow-up visits for 1 year.

Conclusion: Aggressive angiomyxoma is one of the differential diagnoses for vulvovaginal growth in a female. As the tumor is well known for local recurrences, correct diagnosis and appropriate management using a multidisciplinary approach are crucial to managing such patients.

Keywords: Angiomyxoma; GnRH agonist; Gynecology; Local recurrence; Vulva.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests. The authors have no association with financial or nonfinancial organizations.

Figures

Fig. 1
Fig. 1
A large, well-defined pedunculated mass arising from left labium majora with overlying skin ulceration
Fig. 2
Fig. 2
Histological section [hematoxylin and eosin (H&E), ×100] showing blood vessels of varying size against myxoid background
See this image and copyright information in PMC

References

    1. Steeper TA, Rosai J. Aggressive angiomyxoma of the female pelvis and perineum. Report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm. Am J Surg Pathol. 1983;7:463–475. doi: 10.1097/00000478-198307000-00009. - DOI - PubMed
    1. Hanby AM, Walker C, Tavassoli FA, Devilee P. Pathology and genetics: tumours of the breast and female genital organs. WHO Classification of Tumours series—volume IV. Lyon: IARC Press: 2003. 250pp. ISBN 92 832 2412 4. Breast Cancer Res. 2004;6:133–134. doi: 10.1186/bcr788. - DOI
    1. Gaurav A, Gill P, Khoiwal K, Chowdhuri S, Kapoor D, Chaturvedi J. Aggressive angiomyxoma of the vulva—a rare entity: case report and review of literature. Int J Reprod Contracept Obstet Gynecol. 2020;9:2605. doi: 10.18203/2320-1770.ijrcog20202357. - DOI
    1. Joseph S, Helm J, Villegas E, Figueroa-Bodine J, Anderson J. Aggressive angiomyxoma: a rare cause of a vulvar mass. J Med Oncol Ther. 2020;5:81–83. doi: 10.35841/medical-oncology.5.1.23. - DOI
    1. Rezai S. Aggressive angiomyxoma of the vulva in a teenager, a case report and review of literature. Obstet Gynecol Int J. 2016 doi: 10.15406/ogij.2016.04.00128. - DOI

Publication types