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. 2022 Feb;27(7):2200060.
doi: 10.2807/1560-7917.ES.2022.27.7.2200060.

Risk reduction of severe outcomes in vaccinated COVID-19 cases: an analysis of surveillance data from Estonia, Ireland, Luxembourg and Slovakia, January to November 2021

Gaetano Marrone  1 , Nathalie Nicolay  1 , Nick Bundle  1 , Tommi Karki  1 , Gianfranco Spiteri  1 , Heleene Suija  2 , Kerstin-Gertrud Kärblane  2 , Joël Mossong  3 , Anne Vergison  3 , Maria Avdicova  4 , Adriana Mecochova  5 , Gillian Cullen  6 , Piaras O'Lorcain  6 , Lucia Pastore Celentano  1 , Tarik Derrough  1 , Julien Beauté  1
Affiliations

Risk reduction of severe outcomes in vaccinated COVID-19 cases: an analysis of surveillance data from Estonia, Ireland, Luxembourg and Slovakia, January to November 2021

Gaetano Marrone et al. Euro Surveill. 2022 Feb.

Abstract

Despite high COVID-19 vaccine coverage in the EU/EEA, there are increasing reports of SARS-CoV-2 infections and hospitalisations in vaccinated individuals. Using surveillance data from Estonia, Ireland, Luxembourg and Slovakia (January-November 2021), we estimated risk reduction of severe outcomes in vaccinated cases. Increasing age remains the most important driver of severity, and vaccination significantly reduces risk in all ages for hospitalisation (adjusted relative risk (aRR): 0.32; 95% confidence interval (CI): 0.26-0.39) and death (aRR: 0.20; 95% CI: 0.13-0.29).

Keywords: COVID-19; Europe Union; death; hospitalization; surveillance; vaccination; vaccine effectiveness.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure
Figure
Rate of hospitalisation of COVID-19 cases by vaccination status reported to The European Surveillance System (TESSy), Ireland, Luxembourg and Slovakia, weeks 1–45 2021
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