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Case Reports
. 2020 Jul 30;11(1):67-71.
doi: 10.1055/s-0040-1714707. eCollection 2022 Mar.

Suspected Case of Drug-Induced Acute Respiratory Distress Syndrome following Trimethoprim-Sulfamethoxazole Treatment

Julia Natterer  1 , Frida Rizzati  1 , Marie-Hélène Perez  1 , David Longchamp  1 , Vivianne Amiet  1 , Quentin DeHalleux  2 , Kim Dao  3 , Thomas Ferry  1
Affiliations
Case Reports

Suspected Case of Drug-Induced Acute Respiratory Distress Syndrome following Trimethoprim-Sulfamethoxazole Treatment

Julia Natterer et al. J Pediatr Intensive Care. .

Abstract

In this article, we reported the case of a child patient who was admitted to our PICU for severe acute respiratory distress syndrome (ARDS) while being treated with trimethoprim-sulfamethoxazole (TMP-SMX) for osteomyelitis. Based on the timing of exposure, lack of alternative explanations, and clinical course similar to previously described cases, we suspect that TMP-SMX may have triggered ARDS. Despite meeting criteria for extracorporeal membrane oxygenation cannulation, conservative management and lung recruitment with high-frequency percussive ventilation could avoid the latter.

Keywords: acute respiratory distress syndrome; percussive ventilation; trimethoprim.

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Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
Chest X-ray on hospital day 1 in the PICU, prior to intubation showing diffuse, bilateral infiltrates, pneumomediastinum, and subcutaneous emphysema. PICU, pediatric intensive care unit.
Fig. 2
Fig. 2
CT scan on hospital day 34 showing diffuse, parenchymal abnormalities with predominantly ground-glass appearance. CT, computed tomography.
See this image and copyright information in PMC

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