Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Jul 15;151(2):308-312.
doi: 10.1002/ijc.33967. Epub 2022 Mar 5.

Meta-analysis of agreement/concordance statistics in studies comparing self- vs clinician-collected samples for HPV testing in cervical cancer screening

Marc Arbyn  1   2 , Philip E Castle  3   4 , Mark Schiffman  4 , Nicolas Wentzensen  4 , Brandy Heckman-Stoddard  3 , Vikrant V Sahasrabuddhe  3
Affiliations
Meta-Analysis

Meta-analysis of agreement/concordance statistics in studies comparing self- vs clinician-collected samples for HPV testing in cervical cancer screening

Marc Arbyn et al. Int J Cancer. .

Abstract

We conducted a meta-analysis of test agreement/concordance between human papillomavirus (HPV) testing in self-collected vs clinician-collected samples in 26 studies (10 071 participants) updating a previous meta-analysis on accuracy for cervical precancer. Pooled overall agreement was 88.7% (95% CI: 86.3%-90.9%), positive agreement was 84.6% (95% CI: 79.9%-88.7%), negative agreement was 91.7% (95% CI: 89.1%-94.0%) and kappa was 0.72 (95% CI: 0.66-0.78). Subgroup meta-analyses suggested higher overall agreement for target amplification-based DNA assays (90.4%) compared to signal amplification-based DNA assays (86.7%; P = .175) or RNA assays (82.3%; P < .001). HPV test agreement/concordance targets may provide criteria to extend existing validations toward alternative sampling approaches and devices/storage media.

Keywords: agreement; cervical cancer screening; concordance; human papillomavirus; self-collection.

PubMed Disclaimer

Comment in

References

REFERENCES

    1. Medicaid and CHIP Payment and Access Commission. Access in brief: use of cervical, breast, and colon cancer tests among adult Medicaid enrollees. Washington, DC: MACPAC; 2016. https://www.macpac.gov/wp-content/uploads/2016/11/Use-of-Cervical-Breast...
    1. Lim AWW. Will COVID-19 be the tipping point for primary HPV self-sampling? Cancer Epidemiol Biomarkers Prev. 2021;30:245-247.
    1. Leyden WA, Manos MM, Geiger AM, et al. Cervical cancer in women with comprehensive health care access: attributable factors in the screening process. J Natl Cancer Inst. 2005;97:675-683.
    1. Benard VB, Jackson JE, Greek A, et al. A population study of screening history and diagnostic outcomes of women with invasive cervical cancer. Cancer Med. 2021;10:4127-4137.
    1. Arbyn M, Smith SB, Temin S, Sultana F, Castle P, Collaboration on Self-Sampling and HPV Testing. Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses. BMJ. 2018;363:k4823.

Publication types