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. 2022 Jan;109(1):E5-E7.
doi: 10.12788/cutis.0423.

Herpes Zoster Following a Nucleoside-Modified Messenger RNA COVID-19 Vaccine

Frédéric Dezoteux  1 , Édouard Massip  1 , Pierre Marcant  1 , Annie Sobaszek  1 , Marie Charlotte Chopin  1 , Fanny Vuotto  1 , Delphine Staumont-Sallé  1
Affiliations

Herpes Zoster Following a Nucleoside-Modified Messenger RNA COVID-19 Vaccine

Frédéric Dezoteux et al. Cutis. 2022 Jan.

Abstract

Herpes zoster (HZ) was suspected as a predictive cutaneous manifestation of COVID-19, with a debated prognostic significance. We report a series of 5 cases of HZ occurring after vaccination with a nucleoside-modified messenger RNA (mRNA) COVID-19 vaccine (Comirnaty, Pfizer-BioNTech). These new cases do not prove causality between COVID-19 vaccination and HZ. The pathophysiologic mechanism remains elusive, but local vaccine-induced immunomodulation may be involved. The occurrence of HZ does not justify avoiding the second injection of vaccine due to the benefit of vaccination.

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