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Comment
. 2022 Feb 17;185(4):581-584.
doi: 10.1016/j.cell.2022.01.005.

Time matters: Human blastoids resemble the sequence of blastocyst development

Ronghui Li  1 , Cuiqing Zhong  2 , Juan Carlos Izpisua Belmonte  3
Affiliations
Free article
Comment

Time matters: Human blastoids resemble the sequence of blastocyst development

Ronghui Li et al. Cell. .
Free article

Abstract

In a recent issue of Nature, Kagawa et al. reported a highly efficient and robust protocol for generating human blastoids from naive human pluripotent stem cells. The blastoids resemble human blastocysts, follow the sequential lineage specification of blastocyst development, and can attach to endometrial cells with the polar trophectoderm to model implantation.

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Conflict of interest statement

Declaration of interests Juan Carlos Izpisua Belmonte is a member of the Cell Advisory Board.

Comment on

  • Human blastoids model blastocyst development and implantation.
    Kagawa H, Javali A, Khoei HH, Sommer TM, Sestini G, Novatchkova M, Scholte Op Reimer Y, Castel G, Bruneau A, Maenhoudt N, Lammers J, Loubersac S, Freour T, Vankelecom H, David L, Rivron N. Kagawa H, et al. Nature. 2022 Jan;601(7894):600-605. doi: 10.1038/s41586-021-04267-8. Epub 2021 Dec 2. Nature. 2022. PMID: 34856602 Free PMC article.

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