Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun;22(2):100615.
doi: 10.1016/j.repbio.2022.100615. Epub 2022 Feb 15.

Maternal hypothyroidism reduces the expression of the kisspeptin/Kiss1r system in the maternal-fetal interface of rats

Bianca Reis Santos  1 , Jeane Martinha Dos Anjos Cordeiro  1 , Luciano Cardoso Santos  1 , Luciana Santos de Oliveira  1 , Letícia Dias Mendonça  1 , Emilly Oliveira Santos  1 , Isabella Oliveira de Macedo  1 , Raphael Escorsim Szawka  2 , Rogéria Serakides  3 , Juneo Freitas Silva  4
Affiliations

Maternal hypothyroidism reduces the expression of the kisspeptin/Kiss1r system in the maternal-fetal interface of rats

Bianca Reis Santos et al. Reprod Biol. 2022 Jun.

Abstract

Alterations of circulating and placental levels of kisspeptin have been associated with gestational diseases. However, there are still no studies on the placental and decidual expression of Kiss1 and its receptor Kiss1r in maternal hypothyroidism, which is the aim of this work. We demonstrate that the fetoplacental restriction caused by hypothyroidism in rats is associated with a reduction in the Kiss1r expression and reduced Kiss1 and Kiss1r mRNA levels in the decidua and/or placenta. This demonstrate that fetoplacental restriction in hypothyroid rats is linked with a suppression of the kisspeptin/Kiss1r system at the maternal-fetal interface.

Keywords: Kisspeptin; Placenta; Rat; Thyroid; Trophoblast.

PubMed Disclaimer

LinkOut - more resources