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. 2022 Apr;41(2):101036.
doi: 10.1016/j.accpm.2022.101036. Epub 2022 Feb 16.

Epidemiology and complications of anaesthesia in the French centres that participated to NECTARINE: A secondary analysis

Souhayl Dahmani  1 , Anne Laffargue  2 , Christophe Dadure  3 , Mathilde De Queiroz  4 , Florence Julien-Marsollier  5 , Daphné Michelet  6 , Francis Veyckemans  2 , Catherine Amory  7 , Hugues Ludot  7 , Dina Bert  8 , Juliette Godart  8 , Anne Laffargue  8 , Hervé Dupont  9 , Benjamin Urbina  9 , Catherine Baujard  10 , Philippe Roulleau  10 , Giuseppe Staiti  10 , Maryline Bordes  11 , Karine Nouette Gaulain  11 , Yann Hamonic  11 , François Semjen  11 , Olivier Jacqmarcq  12 , Caroline Lejus-Bourdeau  12 , Cécile Magne  12 , Léa Petry  13 , Lilica Ros  13 , Aurélien Zang  13 , Mehdi Bennis  14 , Bernard Coustets  14 , Rose Fesseau  14 , Isabelle Constant  15 , Eliane Khalil  15 , Nada Sabourdin  15 , Noémie Audren  16 , Thomas Descarpentries  16 , Fanny Fabre  16 , Aurélien Legrand  16 , Emilie Druot  17 , Gilles Orliaguet  17 , Lucie Sabau  17 , Lynn Uhrig  17 , François De La Briere  18 , Karin Jonckheer  18 , Jean-Paul Mission  18 , Lucia Scordo  18 , Caroline Couchepin  19 , Christophe Dadure  19 , Pablo De La Arena  19 , Laurent Hertz  19 , Philippe Pirat  19 , Chrystelle Sola  19 , Myriam Bellon  20 , Véronique Depret-Donatien  21 , Anne Lesage  21
Affiliations

Epidemiology and complications of anaesthesia in the French centres that participated to NECTARINE: A secondary analysis

Souhayl Dahmani et al. Anaesth Crit Care Pain Med. 2022 Apr.

Abstract

Introduction: Neonatal and infant anaesthesia are associated with a high risk of perioperative complications. The aim of the current study was to describe those risks in France using the French data from the NECTARINE study.

Material and methods: Data from the French centres that participated to the NECTARINE study were analysed. The primary goal of the study was the description of patients' characteristics, procedures and perioperative management and their comparison with the results of the European NECTARINE study. Secondary outcomes were the description of major perioperative complications and death.

Results: Overall, 926 procedures collected in 15 centres (all teaching hospitals) were analysed. Comparison between the French and European NECTARINE cohorts found few differences related to patients' characteristics and procedures. The rate of interventions for critical events (respiratory, haemodynamic, and metabolic) was similar between the two cohorts. Near-infrared spectroscopy monitoring was used in 12% of procedures. Nearly none of the thresholds for these interventions met the published standards. By day 30, complications (respiratory, haemodynamic, metabolic, renal, and liver failure) and death were observed in 14.4% [95% CI 11.6-16.4]% and 1.8% [95% CI 1.1-2.9] of cases, respectively.

Discussion: Although the health status of the patients in the French cohort was less severe, procedures, management and postoperative complications and mortality rates were similar to the European cohort. However, thresholds for interventions were often inadequate in both cohorts. Efforts should be undertaken to improve the knowledge and use of new monitoring devices in this population.

Keywords: Infants; Mortality; Neonates; Paediatric anaesthesia; Perioperative complications; Practice of anaesthesia.

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