. 2022 Nov;20(11):2474-2484.e3.

doi: 10.1016/j.cgh.2022.02.017. Epub 2022 Feb 16.

International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

Evan S Dellon¹, Nirmala Gonsalves², J Pablo Abonia³, Jeffrey A Alexander⁴, Nicoleta C Arva⁵, Dan Atkins⁶, Stephen E Attwood⁷, Marcus K H Auth⁸, Dominique D Bailey⁹, Luc Biederman¹⁰, Carine Blanchard¹¹, Peter A Bonis¹², Paroma Bose¹³, Albert J Bredenoord¹⁴, Joy W Chang¹⁵, Mirna Chehade¹⁶, Margaret H Collins¹⁷, Carlo Di Lorenzo¹⁸, Jorge Amil Dias¹⁹, Ranjan Dohil²⁰, Christophe Dupont²¹, Gary W Falk²², Cristina T Ferreira²³, Adam T Fox²⁴, Robert M Genta²⁵, Thomas Greuter²⁶, Sandeep K Gupta¹³, Ikuo Hirano², Girish S Hiremath²⁷, Jennifer L Horsley-Silva²⁸, Shunji Ishihara²⁹, Norihisa Ishimura²⁹, Elizabeth T Jensen³⁰, Carolina Gutiérrez-Junquera³¹, David A Katzka⁴, Paneez Khoury³², Yoshikazu Kinoshita³³, Kara L Kliewer³, Sibylle Koletzko³⁴, John Leung¹², Chris A Liacouras³⁵, Alfredo J Lucendo³⁶, Lisa J Martin³⁷, Emily C McGowan³⁸, Calies Menard-Katcher³⁹, David C Metz²², Talya L Miller⁴⁰, Fouad J Moawad⁴¹, Amanda B Muir³⁵, Vincent A Mukkada⁴², Simon Murch⁴³, Quan M Nhu⁴⁴, Ichiro Nomura⁴⁵, Samuel Nurko⁴⁶, Yoshikazu Ohtsuka⁴⁷, Salvatore Oliva⁴⁸, Rok Orel⁴⁹, Alexandra Papadopoulou⁵⁰, Dhyanesh A Patel⁵¹, Robert D Pesek⁵², Kathryn A Peterson⁵³, Hamish Philpott⁵⁴, Philip E Putnam⁴², Joel E Richter⁵⁵, Rachel Rosen⁵⁶, Melanie A Ruffner⁵⁷, Ekaterina Safroneeva⁵⁸, Philipp Schreiner¹⁰, Alain Schoepfer⁵⁹, Shauna R Schroeder⁶⁰, Neil Shah⁶¹, Rhonda F Souza⁶², Stuart J Spechler⁶², Jonathan M Spergel⁵⁷, Alex Straumann¹⁰, Nicholas J Talley⁶³, Nikhil Thapar⁶⁴, Yvan Vandenplas⁶⁵, Rajitha D Venkatesh¹⁸, Mario C Vieira⁶⁶, Ulrike von Arnim⁶⁷, Marjorie M Walker⁶⁸, Joshua B Wechsler⁶⁹, Barry K Wershil⁶⁹, Benjamin L Wright⁷⁰, Yoshiyuki Yamada⁷¹, Guang-Yu Yang⁷², Noam Zevit⁷³, Marc E Rothenberg³, Glenn T Furuta³⁹, Seema S Aceves⁷⁴

Affiliations

¹ Center for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina. Electronic address: edellon@med.unc.edu.
² Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
³ Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
⁴ Division of Gastroenterology, Mayo Clinic Rochester, Minnesota.
⁵ Department of Pathology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁶ Section of Pediatric Allergy and Immunology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
⁷ Department of Health Services Research, Durham University, Durham, United Kingdom.
⁸ Department of Paediatric Gastroenterology, Hepatology and Nutrition, Alder Hey Children's NHS Foundation Trust and University of Liverpool, Liverpool, United Kingdom.
⁹ Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York; Division of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York; Columbia Center for Human Development, Columbia University Irving Medical Center, New York, New York.
¹⁰ Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
¹¹ Department of Gastro-Intestinal Health, Immunology group, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Lausanne, Switzerland.
¹² Division of Gastroenterology, Tufts University School of Medicine, Boston, Massachusetts.
¹³ Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Riley Hospital for Children and Community Health Network, Indiana University School of Medicine, Indianapolis, Indianapolis.
¹⁴ Department of Gastroenterology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
¹⁵ Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MichiganI.
¹⁶ Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, New York.
¹⁷ Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
¹⁸ Division of Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, Ohio.
¹⁹ Hospital Lusiadas, Porto, Portugal.
²⁰ Division on Pediatric Gastroenterology, Rady's Children's Hospital, University of California, San Diego, San Diego, California.
²¹ Ramsay Group, Marcel Sembat Clinic, Paris Descartes University, Paris, France.
²² Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania.
²³ Hospital Santo Antônio, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
²⁴ Paediatric Allergy, Guy's & St. Thomas' Hospitals NHS Foundation Trust, London, United Kingdom.
²⁵ Division of Gastroenterology, Department of Pathology and Medicine, Baylor College of Medicine, Houston, Texas; Inform Diagnostics, Irving, Texas.
²⁶ Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; Division of Gastroenterology and Hepatology, University Hospital Lausanne, Lausanne, Switzerland.
²⁷ Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee.
²⁸ Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona.
²⁹ Department of Internal Medicine II, Shimane University Faculty of Medicine, Shimane, Japan.
³⁰ Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina.
³¹ Pediatric Gastroenterology Unit, University Hospital Puerta de Hierro Majadahonda, Autonomous University of Madrid, Majadahonda, Spain.
³² Human Eosinophil Section, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, Maryland.
³³ Hyogo Prefectural Harima-Himeji General Medical Center, Himeji, Japan.
³⁴ Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany; Department of Pediatrics, Gastroenterology and Nutrition, School of Medicine Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland.
³⁵ Center for Pediatric Eosinophilic Disorders, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
³⁶ Department of Gastroenterology, Hospital General de Tomelloso, Instituto de Investigación Sanitaria Princesa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Tomelloso, Spain.
³⁷ Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio.
³⁸ Division of Allergy and Immunology, University of Virginia School of Medicine, Charlottesville, Virginia.
³⁹ Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado; Gastrointestinal Eosinophilic Diseases Program, University of Colorado School of Medicine, Aurora, Colorado.
⁴⁰ Swedish Medical Center, Seattle, Washington.
⁴¹ Division of Gastroenterology and Hepatology, Scripps Clinic, La Jolla, California.
⁴² Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
⁴³ Warwick University Medical School, Coventry, United Kingdom.
⁴⁴ Division of Gastroenterology and Hepatology, Scripps Clinic, La Jolla, California; Department of Molecular Medicine, Scripps Research Institute, San Diego, California; Division of Allergy and Immunology, University of California, San Diego, La Jolla, California.
⁴⁵ Division of Eosinophilic Gastrointestinal Disorders, Allergy Center, National Center for Child Health and Development, Tokyo, Japan.
⁴⁶ Center for Motility and Functional Gastrointestinal Disorders, Boston Children's Hospital, Boston, Massachusetts.
⁴⁷ Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁴⁸ Pediatric Digestive Endoscopy, Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, University Hospital, University of Rome, Rome, Italy.
⁴⁹ University Children's Hospital Ljubljana, Faculty of Medicine, University of Ljubljana, Slovenia.
⁵⁰ Division of Gastroenterology and Hepatology, Children's Hospital Agia Sofia, First Department of Pediatrics, University of Athens, Athens, Greece.
⁵¹ Center for Esophageal Disorders, Vanderbilt University Medical Center, Nashville, Tennessee.
⁵² Division of Allergy and Immunology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
⁵³ Division of Gastroenterology, University of Utah, Salt Lake City, Utah.
⁵⁴ Department of Gastroenterology, Lyell McEwin Hospital, University of Adelaide, Adelaide, Australia.
⁵⁵ Morsani College of Medicine, University of South Florida, Tampa, Florida.
⁵⁶ Aerodigestive Center, Boston Children's Hospital, Boston, Massachusetts.
⁵⁷ Division of Allergy and Immunology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
⁵⁸ Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
⁵⁹ Division of Gastroenterology and Hepatology, University Hospital Lausanne, Lausanne, Switzerland.
⁶⁰ Division of Gastroenterology, Hepatology, and Nutrition, Phoenix Children's Hospital, Phoenix, Arizona.
⁶¹ Portland Hospital, London, United Kingdom; Reckitt Healthcare, Slough, United Kingdom.
⁶² Division of Gastroenterology and Center for Esophageal Diseases, Baylor Scott & White Center for Esophageal Research, Baylor University Medical Center, Baylor Scott & White Research Institute, Dallas, Texas.
⁶³ School of Medicine and Public Health, University of Newcastle, Newcastle, Australia; National Health and Medical Research Council Centre of Research Excellence on Digestive Health, Newcastle, Australia; Hunter Medical Research Institute, New Lambton Heights, Australia.
⁶⁴ Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children's Hospital, School of Medicine, University of Queensland, Brisbane, Australia; Woolworths Centre for Child Nutrition Research, Queensland University of Technology, Brisbane, Australia.
⁶⁵ KidZ Health Castle, Vrije Universiteit Brussel, Brussels, Belgium.
⁶⁶ Center for Pediatric Gastroenterology, Hospital Pequeno Príncipe, Curitiba, Brazil.
⁶⁷ Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Magdeburg, Magdeburg, Germany.
⁶⁸ Department of Pathology, College of Health, Medicine and Wellbeing, Faculty of Health and Medicine, University of Newcastle Callaghan, Australia.
⁶⁹ Division of Gastroenterology, Hepatology, and Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
⁷⁰ Division of Allergy, Asthma, and Clinical Immunology, Department of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona; Section of Allergy and Immunology, Division of Pulmonology, Phoenix Children's Hospital, Phoenix, Arizona.
⁷¹ Department of Pediatrics, Tokai University School of Medicine, Kanagawa, Japan.
⁷² Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁷³ Institute of Gastroenterology, Hepatology, and Nutrition, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel-Aviv University, Petah-Tikva, Israel.
⁷⁴ Division of Allergy, Immunology, and Rheumatology, Departments of Pediatrics and Medicine, Rady Children's Hospital, University of California San Diego, San Diego, California.

PMID: 35181570
PMCID: PMC9378753
DOI: 10.1016/j.cgh.2022.02.017

International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

Evan S Dellon et al. Clin Gastroenterol Hepatol. 2022 Nov.

. 2022 Nov;20(11):2474-2484.e3.

doi: 10.1016/j.cgh.2022.02.017. Epub 2022 Feb 16.

Authors

Affiliations

¹ Center for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina. Electronic address: edellon@med.unc.edu.
² Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
³ Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
⁴ Division of Gastroenterology, Mayo Clinic Rochester, Minnesota.
⁵ Department of Pathology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁶ Section of Pediatric Allergy and Immunology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
⁷ Department of Health Services Research, Durham University, Durham, United Kingdom.
⁸ Department of Paediatric Gastroenterology, Hepatology and Nutrition, Alder Hey Children's NHS Foundation Trust and University of Liverpool, Liverpool, United Kingdom.
⁹ Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York; Division of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York; Columbia Center for Human Development, Columbia University Irving Medical Center, New York, New York.
¹⁰ Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
¹¹ Department of Gastro-Intestinal Health, Immunology group, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Lausanne, Switzerland.
¹² Division of Gastroenterology, Tufts University School of Medicine, Boston, Massachusetts.
¹³ Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Riley Hospital for Children and Community Health Network, Indiana University School of Medicine, Indianapolis, Indianapolis.
¹⁴ Department of Gastroenterology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
¹⁵ Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MichiganI.
¹⁶ Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, New York.
¹⁷ Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
¹⁸ Division of Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, Ohio.
¹⁹ Hospital Lusiadas, Porto, Portugal.
²⁰ Division on Pediatric Gastroenterology, Rady's Children's Hospital, University of California, San Diego, San Diego, California.
²¹ Ramsay Group, Marcel Sembat Clinic, Paris Descartes University, Paris, France.
²² Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania.
²³ Hospital Santo Antônio, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
²⁴ Paediatric Allergy, Guy's & St. Thomas' Hospitals NHS Foundation Trust, London, United Kingdom.
²⁵ Division of Gastroenterology, Department of Pathology and Medicine, Baylor College of Medicine, Houston, Texas; Inform Diagnostics, Irving, Texas.
²⁶ Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; Division of Gastroenterology and Hepatology, University Hospital Lausanne, Lausanne, Switzerland.
²⁷ Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee.
²⁸ Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona.
²⁹ Department of Internal Medicine II, Shimane University Faculty of Medicine, Shimane, Japan.
³⁰ Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina.
³¹ Pediatric Gastroenterology Unit, University Hospital Puerta de Hierro Majadahonda, Autonomous University of Madrid, Majadahonda, Spain.
³² Human Eosinophil Section, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, Maryland.
³³ Hyogo Prefectural Harima-Himeji General Medical Center, Himeji, Japan.
³⁴ Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany; Department of Pediatrics, Gastroenterology and Nutrition, School of Medicine Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland.
³⁵ Center for Pediatric Eosinophilic Disorders, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
³⁶ Department of Gastroenterology, Hospital General de Tomelloso, Instituto de Investigación Sanitaria Princesa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Tomelloso, Spain.
³⁷ Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio.
³⁸ Division of Allergy and Immunology, University of Virginia School of Medicine, Charlottesville, Virginia.
³⁹ Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado; Gastrointestinal Eosinophilic Diseases Program, University of Colorado School of Medicine, Aurora, Colorado.
⁴⁰ Swedish Medical Center, Seattle, Washington.
⁴¹ Division of Gastroenterology and Hepatology, Scripps Clinic, La Jolla, California.
⁴² Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
⁴³ Warwick University Medical School, Coventry, United Kingdom.
⁴⁴ Division of Gastroenterology and Hepatology, Scripps Clinic, La Jolla, California; Department of Molecular Medicine, Scripps Research Institute, San Diego, California; Division of Allergy and Immunology, University of California, San Diego, La Jolla, California.
⁴⁵ Division of Eosinophilic Gastrointestinal Disorders, Allergy Center, National Center for Child Health and Development, Tokyo, Japan.
⁴⁶ Center for Motility and Functional Gastrointestinal Disorders, Boston Children's Hospital, Boston, Massachusetts.
⁴⁷ Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁴⁸ Pediatric Digestive Endoscopy, Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, University Hospital, University of Rome, Rome, Italy.
⁴⁹ University Children's Hospital Ljubljana, Faculty of Medicine, University of Ljubljana, Slovenia.
⁵⁰ Division of Gastroenterology and Hepatology, Children's Hospital Agia Sofia, First Department of Pediatrics, University of Athens, Athens, Greece.
⁵¹ Center for Esophageal Disorders, Vanderbilt University Medical Center, Nashville, Tennessee.
⁵² Division of Allergy and Immunology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
⁵³ Division of Gastroenterology, University of Utah, Salt Lake City, Utah.
⁵⁴ Department of Gastroenterology, Lyell McEwin Hospital, University of Adelaide, Adelaide, Australia.
⁵⁵ Morsani College of Medicine, University of South Florida, Tampa, Florida.
⁵⁶ Aerodigestive Center, Boston Children's Hospital, Boston, Massachusetts.
⁵⁷ Division of Allergy and Immunology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
⁵⁸ Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
⁵⁹ Division of Gastroenterology and Hepatology, University Hospital Lausanne, Lausanne, Switzerland.
⁶⁰ Division of Gastroenterology, Hepatology, and Nutrition, Phoenix Children's Hospital, Phoenix, Arizona.
⁶¹ Portland Hospital, London, United Kingdom; Reckitt Healthcare, Slough, United Kingdom.
⁶² Division of Gastroenterology and Center for Esophageal Diseases, Baylor Scott & White Center for Esophageal Research, Baylor University Medical Center, Baylor Scott & White Research Institute, Dallas, Texas.
⁶³ School of Medicine and Public Health, University of Newcastle, Newcastle, Australia; National Health and Medical Research Council Centre of Research Excellence on Digestive Health, Newcastle, Australia; Hunter Medical Research Institute, New Lambton Heights, Australia.
⁶⁴ Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children's Hospital, School of Medicine, University of Queensland, Brisbane, Australia; Woolworths Centre for Child Nutrition Research, Queensland University of Technology, Brisbane, Australia.
⁶⁵ KidZ Health Castle, Vrije Universiteit Brussel, Brussels, Belgium.
⁶⁶ Center for Pediatric Gastroenterology, Hospital Pequeno Príncipe, Curitiba, Brazil.
⁶⁷ Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Magdeburg, Magdeburg, Germany.
⁶⁸ Department of Pathology, College of Health, Medicine and Wellbeing, Faculty of Health and Medicine, University of Newcastle Callaghan, Australia.
⁶⁹ Division of Gastroenterology, Hepatology, and Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
⁷⁰ Division of Allergy, Asthma, and Clinical Immunology, Department of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona; Section of Allergy and Immunology, Division of Pulmonology, Phoenix Children's Hospital, Phoenix, Arizona.
⁷¹ Department of Pediatrics, Tokai University School of Medicine, Kanagawa, Japan.
⁷² Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁷³ Institute of Gastroenterology, Hepatology, and Nutrition, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel-Aviv University, Petah-Tikva, Israel.
⁷⁴ Division of Allergy, Immunology, and Rheumatology, Departments of Pediatrics and Medicine, Rady Children's Hospital, University of California San Diego, San Diego, California.

PMID: 35181570
PMCID: PMC9378753
DOI: 10.1016/j.cgh.2022.02.017

Abstract

Background & aims: Substantial heterogeneity in terminology used for eosinophilic gastrointestinal diseases (EGIDs), particularly the catchall term "eosinophilic gastroenteritis," limits clinical and research advances. We aimed to achieve an international consensus for standardized EGID nomenclature.

Methods: This consensus process utilized Delphi methodology. An initial naming framework was proposed and refined in iterative fashion, then assessed in a first round of Delphi voting. Results were discussed in 2 consensus meetings, and the framework was updated and reassessed in a second Delphi vote, with a 70% threshold set for agreement.

Results: Of 91 experts participating, 85 (93%) completed the first and 82 (90%) completed the second Delphi surveys. Consensus was reached on all but 2 statements. "EGID" was the preferred umbrella term for disorders of gastrointestinal (GI) tract eosinophilic inflammation in the absence of secondary causes (100% agreement). Involved GI tract segments will be named specifically and use an "Eo" abbreviation convention: eosinophilic gastritis (now abbreviated EoG), eosinophilic enteritis (EoN), and eosinophilic colitis (EoC). The term "eosinophilic gastroenteritis" is no longer preferred as the overall name (96% agreement). When >2 GI tract areas are involved, the name should reflect all of the involved areas.

Conclusions: This international process resulted in consensus for updated EGID nomenclature for both clinical and research use. EGID will be the umbrella term, rather than "eosinophilic gastroenteritis," and specific naming conventions by location of GI tract involvement are recommended. As more data are developed, this framework can be updated to reflect best practices and the underlying science.

Keywords: Classification; Delphi; Eosinophilic Gastroenteritis; Eosinophilic Gastrointestinal Disease; Nomenclature.

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Figures

**Figure 1.**
Variability in responses for how the term “eosinophilic gastroenteritis” is used to reflect different areas of involvement in the GI tract.

**Figure 2.**
Consensus nomenclature framework for eosinophilic gastrointestinal diseases (EGIDs). Note that for naming multiple involved GI segments, representative examples are provided but not all possible combinations are listed.

See this image and copyright information in PMC

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International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

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