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. 2022 Mar;21(3):211-214.
doi: 10.1016/S1474-4422(22)00040-0.

Multiple sclerosis: two decades of progress

Bruce A C Cree  1 , Jorge R Oksenberg  1 , Stephen L Hauser  2
Affiliations

Multiple sclerosis: two decades of progress

Bruce A C Cree et al. Lancet Neurol. 2022 Mar.
No abstract available

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Figures

Figure:
Figure:. Advances in Multiple Sclerosis 2002–2022.
Overview of research (blue) and therapeutic (orange) advances in multiple sclerosis over the past 20 years. Left side: year indicates publication date of scientific advance. Right side: year indicates date of first regulatory approval; when designated by an asterisk, indicates year of publication of key clinical trial of an unapproved therapy. a Cross-presentation of DR peptide fragments with EBV, bacterial and myelin proteins. b Specificities directed against a diverse array of (mostly) ubiquitous intracellular targets. *Currently off-label in the USA. APC, antigen-presenting cell; CNS, central nervous system; CSF, cerebrospinal fluid; EBV, Epstein-Barr virus; HLA, human leukocyte antigens; MRI, magnetic resonance imaging: MS, multiple sclerosis; NfL, Neurofilament light chain protein; OCB, oligoclonal bands; SPMS, secondary-progressive multiple sclerosis
See this image and copyright information in PMC

References

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