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. 2022 May:137:207-215.
doi: 10.1016/j.clinph.2022.01.128. Epub 2022 Feb 3.

EEG-based functional connectivity and executive control in patients with Parkinson's disease and freezing of gait

Morgane Gérard  1 , Madli Bayot  1 , Philippe Derambure  1 , Kathy Dujardin  2 , Luc Defebvre  2 , Nacim Betrouni  1 , Arnaud Delval  3
Affiliations

EEG-based functional connectivity and executive control in patients with Parkinson's disease and freezing of gait

Morgane Gérard et al. Clin Neurophysiol. 2022 May.

Abstract

Objective: To explore changes over time in the network specificities underpinning a visual attentional task in patients with Parkinson's disease and freezing of gait (the PD + FoG group), patients with Parkinson's disease but no FoG (PD-FoG), and healthy controls (HCs).

Methods: High-resolution electroencephalography (EEG) data were acquired for 15 PD + FoG patients, 14 PD-FoG patients, and 18 HCs performing the Attention Network Test. After source localization, functional connectivity was assessed and compared by applying the dynamic phase-locking value method.

Results: The PD + FoG patients showed an impairment in executive control. Furthermore, the PD + FoG patients showed abnormally high theta band connectivity (relative to HCs, and 400 to 600 ms after target presentation) in a network connecting the orbitofrontal and occipitotemporal regions.

Conclusions: In PD + FoG, the greater functional connectivity between the visual network and the regions to which executive function has been attributed might indicate greater reliance on environmental features when seeking to overcome the impairment in executive control.

Significance: FoG in PD involves cognitive, attentional and executive dysfunctions. Our observation of abnormally high connectivity in PD + FoG patients argues in favor of the interference model of FoG.

Keywords: Attention Network Test (ANT); Executive control; Functional connectivity; Parkinson’s disease (PD); electroencephalography (EEG); freezing of gait (FoG).

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [None of the authors has conflicts of interest directly related to the present study. M. Gerard received a grant from Lille University for a research year. M. Bayot received a Marie Sklodowska-Curie fellowship (reference: 721577) as part of the European Union’s Horizon 2020 research and innovation program. L. Defebvre has received consultancy fees from Abbvie and Orkyn and has received speaker’s fees from UCB and Abbvie. N. Betrouni is a staff researcher at the Institut National de la Santé et de la Recherche Médicale. He has received a grant from PROCOPE Campus France and has received consultancy fees from LLL France.].

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