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. 2022 Apr;84(4):e34-e35.
doi: 10.1016/j.jinf.2022.02.013. Epub 2022 Feb 17.

Decline of immune humoral response after BNT162b2 vaccine

Sonia Ferri  1 , Alessandro Polidoro  1 , Marco Ciacciarelli  1 , Umberto Ceratti  1 , Viviana Congedo  1 , Maria Mele  2 , Graziella Coluzzi  2 , Alessandra Spagnoli  3 , Luigi Iuliano  4
Affiliations

Decline of immune humoral response after BNT162b2 vaccine

Sonia Ferri et al. J Infect. 2022 Apr.
No abstract available

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Figures

Fig 1
Fig. 1
Decay of anti-SP Ab in the population. Levels of serum anti-SP IgG (arbitrary units, median ± IQR) in the whole population at 6, 15, and 28 weeks of follow up; inset, percent decay.
Fig 2
Fig. 2
Anti-SP IgG titer in study participants as function of vaccination status and Covid-19 positivity. Participants with incomplete vaccination that resulted positive to Covid-19 (n = 28, red line) had a lower anti-SP IgG titer at peak immunity (log transformed value, mean, 95% CI), but not at 28 weeks, compared to participants with full vaccination status (2 jabs) (n = 614, green line). Among participants with complete vaccination, those with history of Covid-19 (n = 37, blue line) had higher anti-SP IgG titer at peak vaccination and persistently higher titer throughout the study period compared to Covid-19 negative ones.
See this image and copyright information in PMC

References

    1. Tré-Hardy M., Cupaiolo R., Wilmet A., et al. Immunogenicity of mRNA-1273 COVID vaccine after 6 months surveillance in health care workers; a third dose is necessary. J Infect. 2021;83:559–564. - PMC - PubMed
    1. Earle K.A., Ambrosino D.M., Fiore-Gartland A., et al. Evidence for antibody as a protective correlate for COVID-19 vaccines. Vaccine. 2021;39:4423–4428. - PMC - PubMed
    1. Levin E.G., Lustig Y., Cohen C., et al. Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months. N Engl J Med. 2021;385:e84. - PMC - PubMed
    1. Goel R.R., Painter M.M., Apostolidis S.A., et al. mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Science. 2021:374. abm0829. - PMC - PubMed
    1. Gilbert P.B., Montefiori D.C., McDermott A.B., et al. Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial. Science. 2021 eab3435. - PMC - PubMed