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. 2022 May;57(5):827-829.
doi: 10.1038/s41409-022-01612-x. Epub 2022 Feb 19.

Ionizing radiation exposure after allogeneic hematopoietic cell transplantation

Christina Cho  1   2 , Molly A Maloy  3 , Sean M Devlin  4 , Omer Aras  5   6 , Lawrence T Dauer  6   7 , Ann A Jakubowski  3   5 , Esperanza B Papadopoulos  3   5 , Miguel-Angel Perales  3   5 , Theodore S Rappaport  8 , Sergio A Giralt  3   5
Affiliations

Ionizing radiation exposure after allogeneic hematopoietic cell transplantation

Christina Cho et al. Bone Marrow Transplant. 2022 May.
No abstract available

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Conflict of interest statement

CC, MAM, SMD, OA, LTD, AAJ, EBP, and TSR: none. MAP: Reports honoraria from Abbvie, Astellas, Celgene, Bristol-Myers Squibb, Incyte, Karyopharm, Kite/Gilead, Merck, Miltenyi Biotec, MorphoSys, Novartis, Nektar Therapeutics, Omeros, and Takeda. He serves on DSMBs for Cidara Therapeutics, Servier and Medigene and the scientific advisory board of NexImmune. He has received research support for clinical trials from Incyte, Kite/Gilead, Miltenyi Biotec, and Novartis. He serves in a volunteer capacity as a member of the Board of Directors of Be The Match (National Marrow Donor Program, NMDP), as well as on the CIBMTR Cellular Immunotherapy Data Resource (CIDR) Executive Committee. SAG: Reports honoraria and consulting fees from Actinium, Amgen, Celgene, Jazz Scientific, Kite, Novartis, Omeros, and Miltenyi; and research funding from Actinium, Amgen, BMS, Celgene, Janssen, Novartis, Miltenyi, Pfizer, Sanofi, and Takeda. He has served on scientific advisory boards for Actinium, BMS, Celgene, GSK, Jazz Scientific, Janssen, Pfizer, and Sanofi.

Figures

Fig. 1
Fig. 1. Outcomes among recipients of CD34+ cell-selected PBSCT based on imaging-related radiation exposure, below vs. above the median.
a Cumulative incidence of relapse. b Cumulative incidence of subsequent neoplasm.
See this image and copyright information in PMC

References

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    1. Meulepas JM, Ronckers CM, Smets A, Nievelstein RAJ, Gradowska P, Lee C, et al. Radiation exposure from pediatric CT scans and subsequent cancer risk in the Netherlands. J Natl Cancer Inst. 2019;111:256–63. - PMC - PubMed
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    1. Jakubowski AA. T cell depleted stem-cell transplantation for adults with hematologic malignancies: sustained engraftment of HLA-matched related donor grafts without the use of antithymocyte globulin. Blood. 2007;110:4552–9. - PMC - PubMed

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