Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Mar;14(5):279-293.
doi: 10.2217/epi-2020-0348. Epub 2022 Feb 21.

Harnessing the role of epigenetic histone modification in targeting head and neck squamous cell carcinoma

Surabhi Suchanti  1 , Bjorn J Stephen  1 , Sonali Awasthi  2 , Sudhir K Awasthi  2 , Gyanendra Singh  3 , Abhijeet Singh  1 , Rajeev Mishra  2
Affiliations
Review

Harnessing the role of epigenetic histone modification in targeting head and neck squamous cell carcinoma

Surabhi Suchanti et al. Epigenomics. 2022 Mar.

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent form of cancer worldwide. Despite advancements made in treatment strategies, the fatality rate of HNSCC is very high. An accumulating body of evidence suggests that epigenetic modification of histones plays an influential role in the development and progression of the disease. In this review we discuss the role of epigenetic modifications in HNSCC and the inter-relationships of human papillomavirus oncoproteins and histone-modifying agents. Further, we explore the possibility of identifying these modifications as biomarkers for their use as drugs in treatment strategies.

Keywords: HNSCC; HPV; epigenetics; histone modification; therapies.

Plain language summary

Head and neck squamous cell carcinoma (HNSCC) is the most common kind of head and neck cancer. HNSCC can develop therapeutic resistance, making therapy more difficult. Many studies have found that epigenetic events play a key role in HNSCC. Better understanding epigenetic regulation could help discovery of biomarkers that help detect and diagnose HNSCC. This review will present recent studies, showing the importance of epigenetic regulation targeting histone modifications in the development of HNSCC.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources