Perioperative Management of Immunosuppressive Medications for Rheumatoid Arthritis

Abstract

Operations in patients with rheumatoid arthritis are complicated by the fact that most drugs used in medical management have immunosuppressive mechanisms of action, including corticosteroids and conventional synthetic and biologic disease-modifying antirheumatic drugs. In deciding to continue or discontinue these medications perioperatively, surgeons must weigh the relative risk of infection from immunosuppression against the risk of rheumatoid arthritis symptom flares from reduced medical disease control. The objective of this article is to review the existing evidence regarding perioperative management of immunosuppressive rheumatoid arthritis medications, with a specific focus on relevance to hand and upper-extremity procedures.

Keywords: Biologic synthetic disease-modifying antirheumatic drugs; conventional synthetic disease-modifying antirheumatic drugs; corticosteroids; disease-modifying antirheumatic drugs; rheumatoid arthritis.