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Meta-Analysis
. 2022 Feb 2:2022:6456272.
doi: 10.1155/2022/6456272. eCollection 2022.

Patent Foramen Ovale Closure for Treating Migraine: A Meta-Analysis

Yu Zhang  1   2 , Haijiao Wang  1 , Ling Liu  1
Affiliations
Meta-Analysis

Patent Foramen Ovale Closure for Treating Migraine: A Meta-Analysis

Yu Zhang et al. J Interv Cardiol. .

Abstract

Background: Observational studies have shown percutaneous patent foramen ovale (PFO) closure to be a safe means of reducing the frequency and duration of migraine.

Objective: This study evaluated the efficacy and safety of PFO closure in patients with migraine using evidence-based medicine.

Methods: The Pubmed (MEDLINE), Embase, and Cochrane Library databases were searched for randomized controlled trials (RCTs), cohort studies, and retrospective case series from January 1, 2001, to February 30, 2021. The Jadad scale and R 4.1.0 software were used to assess the quality of the literature and meta-analysis, respectively.

Results: In total, three randomized controlled trials, one pooled study, and eight retrospective case series including 1,165 participants were included in the meta-analysis. Compared with control intervention in migraine, PFO closure could significantly reduce headache frequency (OR = 1.5698, 95% CI: 1.0465-2.3548, p=0.0293) and monthly migraine attacks and monthly migraine days (OR = 0.2594, 95% CI: 0.0790-0.4398, p=0.0048). Subgroup analysis of patients who all completed PFO surgery showed resolution of migraine headache for migraines with aura (OR = 1.5856, 95% CI: 1.0665-2.3575, p=0.0227).

Conclusions: Treatment with PFO closure could reduce the frequency of headaches and monthly migraine days and is an efficient treatment for migraine attacks with aura.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of screening literature.
Figure 2
Figure 2
Forest plot for 50% reduction in monthly migraine attacks and monthly migraine days.
Figure 3
Figure 3
Forest plot for complete resolution of migraine headache.
Figure 4
Figure 4
Forest plot for reduction in monthly migraine attacks and monthly migraine days.
Figure 5
Figure 5
Forest plot for resolution of migraine headache for migraine with aura.
Figure 6
Figure 6
Funnel plots of the 3 RCT studies.
Figure 7
Figure 7
Funnel plots of the 8 RCS studies.
See this image and copyright information in PMC

References

    1. Schwedt T. J., Demaerschalk B. M., Dodick D. W. Patent foramen ovale and migraine: a quantitative systematic review. Cephalalgia . 2008;28(5):531–540. doi: 10.1111/j.1468-2982.2008.01554.x. - DOI - PubMed
    1. Mahmoud A. N., Mentias A., Elgendy A. Y., et al. Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1 152 407 subjects. BMJ Open . 2018;8(3) doi: 10.1136/bmjopen-2017-020498.e020498 - DOI - PMC - PubMed
    1. Shi Y. J., Lv J., Han X. T., Luo G. G. Migraine and percutaneous patent foramen ovale closure: a systematic review and meta-analysis. BMC Cardiovascular Disorders . 2017;17(1):p. 203. doi: 10.1186/s12872-017-0644-9. - DOI - PMC - PubMed
    1. Kanwar S. M., Noheria A., DeSimone C. V., Rabinstein A. A., Asirvatham S. J. Coincidental impact of transcatheter patent foramen ovale closure on migraine with and without Aura–a comprehensive meta-analysis. Clinical Trials and Regulatory Science in Cardiology . 2016;15:7–13. doi: 10.1016/j.ctrsc.2016.01.002. - DOI - PMC - PubMed
    1. Mojadidi M. K., Bogush N., Caceres J. D., Msaouel P., Tobis J. M. Diagnostic accuracy of transesophageal echocardiogram for the detection of patent foramen ovale: a meta-analysis. Echocardiography . 2014;31(6):752–758. doi: 10.1111/echo.12462. - DOI - PubMed

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