Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 9:2022:1345071.
doi: 10.1155/2022/1345071. eCollection 2022.

Association between the Oxidative Balance Score and Telomere Length from the National Health and Nutrition Examination Survey 1999-2002

Wan Zhang  1 , Shu-Fen Peng  1 , Li Chen  1 , Hui-Min Chen  1 , Xue-Er Cheng  1 , Yu-Han Tang  1
Affiliations

Association between the Oxidative Balance Score and Telomere Length from the National Health and Nutrition Examination Survey 1999-2002

Wan Zhang et al. Oxid Med Cell Longev. .

Abstract

Purpose: Leukocyte telomere length (LTL) is an important biomarker of aging. The oxidative balance score (OBS) is used to assess the oxidative stress-related exposures of diet and lifestyle. This study is aimed at exploring if the OBS was associated with LTL.

Methods: 3220 adults were included in this study from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. LTL was assayed from leukocyte DNA. Twenty dietary and lifestyle factors were selected to score the OBS. Survey-based multivariable linear regression was conducted to assess the association between the OBS and log-transformed LTL.

Results: The association between the OBS and log-transformed LTL was positive in females but not males. For females, compared with the lowest OBS category as a reference, the multivariable-adjusted beta estimate (95% confidence interval, CI) for the highest OBS category was 0.0701 (0.0205-0.1197) (p for trend < 0.01), and the multivariable-adjusted beta estimate (95% CI) of the continuous OBS was 0.0039 (0.0014-0.0065). There was also the gender difference in the correlations of the dietary OBS and the lifestyle OBS with log-transformed LTL.

Conclusion: There was a positive association between the OBS and LTL in females. This result suggested that diet and lifestyle might affect LTL by regulating oxidative balance.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart depicting the selection strategy.
See this image and copyright information in PMC

References

    1. Blackburn E. H., Epel E. S., Lin J. Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection. Science . 2015;350(6265):1193–1198. doi: 10.1126/science.aab3389. - DOI - PubMed
    1. Xu M., Pirtskhalava T., Farr J. N., et al. Senolytics improve physical function and increase lifespan in old age. Nature Medicine . 2018;24(8):1246–1256. doi: 10.1038/s41591-018-0092-9. - DOI - PMC - PubMed
    1. Babizhayev M. A., Savel'yeva E. L., Moskvina S. N., Yegorov Y. E. Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior. American Journal of Therapeutics . 2011;18(6):e209–e226. doi: 10.1097/MJT.0b013e3181cf8ebb. - DOI - PubMed
    1. Shay J. W. Role of telomeres and telomerase in aging and cancer. Cancer Discovery . 2016;6(6):584–593. doi: 10.1158/2159-8290.CD-16-0062. - DOI - PMC - PubMed
    1. Ennour-Idrissi K., Maunsell E., Diorio C. Telomere length and breast cancer prognosis: a systematic review. Cancer Epidemiology, Biomarkers & Prevention . 2017;26(1):3–10. doi: 10.1158/1055-9965.EPI-16-0343. - DOI - PubMed

Publication types

LinkOut - more resources