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Review
. 2021 Dec 14;11(1):5-14.
doi: 10.1055/s-0041-1740532. eCollection 2022 Mar.

Genetics Landscape of Nonsyndromic Hearing Loss in Indian Populations

Manisha Ray  1 , Saurav Sarkar  2 , Mukund Namdev Sable  1
Affiliations
Review

Genetics Landscape of Nonsyndromic Hearing Loss in Indian Populations

Manisha Ray et al. J Pediatr Genet. .

Abstract

Congenital nonsyndromic hearing loss (NSHL) has been considered as one of the most prevalent chronic disorder in children. It affects the physical and mental conditions of a large children population worldwide. Because of the genetic heterogeneity, the identification of target gene is very challenging. However, gap junction β-2 ( GJB2 ) is taken as the key gene for hearing loss, as its involvement has been reported frequently in NSHL cases. This study aimed to identify the association of GJB2 mutants in different Indian populations based on published studies in Indian population. This will provide clear genetic fundamental of NSHL in Indian biogeography, which would be helpful in the diagnosis process.

Keywords: GJB2; India; genetics; mutation; nonsyndromic hearing loss.

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Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
Representation of methodology through PRISMA—preferred reporting items for systematic reviews and meta-analyses—flow diagram.
Fig. 2
Fig. 2
Most prevalent protein mutations in GJB2 identified in Indian populations.
Fig. 3
Fig. 3
Occurrence of W24X in GJB2 analyzed in ( A ) individual populations, ( B ) group populations, and ( C ) overall studied nonsyndromic hearing loss cases of different Indian geographical locations.
Fig. 4
Fig. 4
Reported chromosomal mutations, mostly observed in GJB2 .
See this image and copyright information in PMC

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