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. 2022 Feb 4:9:755671.
doi: 10.3389/fsurg.2022.755671. eCollection 2022.

Incidence and Related Factors for Low-Extremity Deep Vein Thrombosis in Breast Cancer Patients Who Underwent Surgical Resection: What Do We Know and What Should We Care

Liqiang Chen  1 , Qiang Feng  2 , Wenjuan Wang  3 , Lanbo Liu  1
Affiliations

Incidence and Related Factors for Low-Extremity Deep Vein Thrombosis in Breast Cancer Patients Who Underwent Surgical Resection: What Do We Know and What Should We Care

Liqiang Chen et al. Front Surg. .

Abstract

Malignancy, surgical resection, and neoadjuvant and/or adjuvant chemotherapy increase the low-extremity deep vein thrombosis (LDVT) risk in patients with breast cancer, bringing in great physical burdens, disabilities, and worse survivals. However, LDVT in surgical breast cancer patients is scarcely reported. Therefore, this study aimed to evaluate the incidence and related factors for LDVT in these patients. Patients with breast cancer who underwent surgical resection were included. LDVT was examined on the day of discharge and 1 month after the discharge. A total of 491 eligible patients were included, among which 11 (2.2%) patients occurred LDVT. Besides, higher age, history of diabetes mellitus, advanced T and tumor node metastasis (TNM) stages, higher platelet count, and shorter activated partial thromboplastin time (APTT) were correlated with increased LDVT incidence (all p < 0.05). Additionally, higher age [p = 0.004, odds ratio (OR) (95% CI): 1.082 (1.023-1.144)], history of diabetes mellitus [p = 0.003, OR (95% CI): 10.426 (2.219-48.986)], and a higher platelet count [p = 0.008, OR (95% CI): 1.017 (1.004-1.029)] were independent factors for increased LDVT incidence, while higher APTT [p = 0.004, OR (95% CI): 0.636 (0.467-0.866)] was an independent factor for decreased LDVT incidence. Lastly, the risk prediction model involving age, history of diabetes mellitus, platelet count, and APTT showed a good ability to predict LDVT occurrence (area under curve: 0.919, 95% CI: 0.869-0.968). In conclusion, the LDVT incidence is 2.2%, and its independent factors consist of age, history of diabetes mellitus, platelet count, and APTT in patients with breast cancer who underwent surgical resection, which provides evidence for the prevention and surveillance of LDVT in surgical breast cancer.

Keywords: breast cancer; incidence; low-extremity deep vein thrombosis; predict model; risk factor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Percentage of LDVT patients in breast cancer patients who underwent surgical resection. LDVT, low-extremity deep vein thrombosis.
Figure 2
Figure 2
Factors impacting LDVT incidence in patients with breast cancer who underwent surgical resection. LDVT, low-extremity deep vein thrombosis; OR, odds ratio; CI, confidence interval; BMI, body mass indexes; HER2+, human epidermal growth factor receptor 2-positive; TNM, tumor, node, and metastasis; WBC, white blood cell; TG, triglyceride; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; PT, prothrombin time; Sec, second; APTT, activated partial thromboplastin time; TT, thrombin time; FIB, fibrinogen.
Figure 3
Figure 3
Independent factors impacting LDVT incidence in patients with breast cancer who underwent surgical resection. LDVT, low-extremity deep vein thrombosis; OR, odds ratio; CI, confidence interval; APTT, activated partial thromboplastin time.
Figure 4
Figure 4
The LDVT prediction model. LDVT, low-extremity deep vein thrombosis; AUC, area under curve; CI, confidence interval. The ability of age, history of diabetes mellitus, platelet count, APTT (A) and the combination of these four factors (B) in predicting LDVT risk.
See this image and copyright information in PMC

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