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. 2022 Feb 4:8:815595.
doi: 10.3389/fcvm.2021.815595. eCollection 2021.

LRP6 Polymorphisms Is Associated With Sudden Cardiac Death in Patients With Chronic Heart Failure in the Chinese Han Population

Qi Guo  1 , Yiwei Lai  1 , Jianmin Chu  2 , Xuhua Chen  2 , Mingyang Gao  1 , Caihua Sang  1 , Jianzeng Dong  1 , Jielin Pu  2   3 , Changsheng Ma  1
Affiliations

LRP6 Polymorphisms Is Associated With Sudden Cardiac Death in Patients With Chronic Heart Failure in the Chinese Han Population

Qi Guo et al. Front Cardiovasc Med. .

Abstract

Low-density lipoprotein receptor-related protein 6 (LRP6) plays a critical role in cardiovascular homeostasis. The deficiency of LRP6 is associated with a high risk of arrhythmias. However, the association between genetic variations of LRP6 and sudden cardiac death (SCD) remains unknown. This study aims to explore the association between common variants of LRP6 and the prognosis of chronic heart failure (CHF) patients. From July 2005 to December 2009, patients with CHF were enrolled from 10 hospitals in China. The single-nucleotide polymorphism (SNP) rs2302684 was selected for the evaluation of the effect of LRP6 polymorphisms on the survival in patients with CHF. A total of 1,437 patients with CHF were finally included for the analysis. During a median follow-up of 61 months (range 0.4-129 months), a total of 546 (38.0%) patients died, including 201 (36.8%) cases with SCD and 345 (63.2%) cases with non-SCD. Patients carrying A allele of rs2302684 had an increased risk of all-cause death (adjusted HR 1.452, 95% CI 1.189-1.706; P < 0.001) and SCD (adjusted HR 1.783, 95% CI 1.337-2.378; P < 0.001). Therefore, the SNP rs2302684 T>A in LRP6 indicated higher risks of all-cause death and SCD in patients with CHF. LRP6 could be added as a novel predictor of SCD and might be a potential therapeutic target in the prevention of SCD in the CHF population.

Keywords: LRP6; chronic heart failure; prognosis; single-nucleotide polymorphism; sudden cardiac death.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Genotyping of the studied population showing the wild type (A) and the variants of rs2302684 T>A (B,C).
Figure 2
Figure 2
Kaplan-Meier curves in the chronic heart failure (CHF) cohort. Patients carrying A allele of rs2302684 were more vulnerable to all-cause death and sudden cardiac death (SCD) than those without it. The table denotes the number of patients at risk for every 20 months of the follow-up.
Figure 3
Figure 3
The effect of A allele of rs2302684 on all-cause mortality and sudden cardiac death in different subgroups, including different ages, sex, and etiology.
See this image and copyright information in PMC

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