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Comment
. 2021 Feb 12;2(2):113-114.
doi: 10.1016/j.medj.2021.01.003.

Ironing Out Vaccine Efficacy

Christian G Peace  1 , Luke A J O'Neill  1
Affiliations
Comment

Ironing Out Vaccine Efficacy

Christian G Peace et al. Med. .

Abstract

Iron deficiency has been linked to impaired humoral immunity to vaccines. In this issue of Med, Frost et al. demonstrate the importance of serum iron levels for lymphocyte function during vaccination and infection, pointing to iron supplementation as a strategy to boost vaccine efficacy, including against COVID19.1.

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Conflict of interest statement

The author declares no competing interests.

Figures

Figure 1
Figure 1
Immunosuppressive Effects of Low Serum Iron on Lymphocytes Under conditions of low serum iron, lymphocytes display impaired responses resulting in decreased mitochondrial function and leading to impaired proliferation, cytokine production, ATP production, antibody production, cytotoxicity, and memory responses. Normal iron levels are needed for all these responses and will promote adaptive immunity, improving host defense or enhancing vaccine efficacy.
See this image and copyright information in PMC

Comment on

  • Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.
    Frost JN, Tan TK, Abbas M, Wideman SK, Bonadonna M, Stoffel NU, Wray K, Kronsteiner B, Smits G, Campagna DR, Duarte TL, Lopes JM, Shah A, Armitage AE, Arezes J, Lim PJ, Preston AE, Ahern D, Teh M, Naylor C, Salio M, Gileadi U, Andrews SC, Dunachie SJ, Zimmermann MB, van der Klis FRM, Cerundolo V, Bannard O, Draper SJ, Townsend ARM, Galy B, Fleming MD, Lewis MC, Drakesmith H. Frost JN, et al. Med. 2021 Feb 12;2(2):164-179.e12. doi: 10.1016/j.medj.2020.10.004. Med. 2021. PMID: 33665641 Free PMC article.

References

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