Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb;192(1):389-393.
doi: 10.1007/s11845-022-02953-8. Epub 2022 Feb 20.

Hyponatremia as a predictor of outcome and mortality: results from a second-level urban emergency department population

Anna Giulia Falchi  1 , Camilla Mascolo  2 , Vincenzo Sepe  3 , Carmelo Libetta  3 , Elisa Bonadeo  4 , Riccardo Albertini  5 , Federica Manzoni  6 , Stefano Perlini  7
Affiliations

Hyponatremia as a predictor of outcome and mortality: results from a second-level urban emergency department population

Anna Giulia Falchi et al. Ir J Med Sci. 2023 Feb.

Abstract

Background: Hyponatremia is the most common electrolyte disorder and it has been associated with increased mortality.

Aims: This study evaluated hyponatremia as a prognostic factor for severity and mortality.

Methods: We compared the prevalence of hyponatremia among patients who died during the year 2017 (from 1 January 2017 to 31 December 2017) with the prevalence of hyponatremia among subgroups of patients, i.e. outpatients, patients hospitalized for more than 2 days and patients admitted in the intensive care unit (ICU). We also described the mortality rate and the prevalence of comorbidities among hyponatremic patients, according to hyponatremia degree (slight, moderate, severe), basal characteristics, comorbidities and their outcome (discharged, hospitalized or died).

Results: In our population of a public hospital setting, hyponatremia was present at admission in 17% of deaths, and the comparison between hyponatremic and normonatremic patients in terms of mortality confirms the hypothesis that this disorder is in anyway strictly associated with vulnerability and with a poor prognosis.

Conclusions: We conclude that hyponatremia is a predictive marker for a bad clinical course, therefore patients with this electrolyte disorder should be carefully monitored.

Keywords: Emergency department; Hyponatremia and mortality; Hyponatremia as a prognostic factor.

PubMed Disclaimer

References

    1. Asadollah K, Beeching N, Gill G (2006) Hyponatraemia as a risk factor for hospital mortality. QJMed 99(12):877–880. https://doi.org/10.1093/qjmed/hcl120 - DOI
    1. Garrahy A, Cuesta M, Murphy B et al (2021) Active management of severe hyponatraemia is associated with improved mortality. CJ Eur J Endocrinol 184(1):9–17. https://doi.org/10.1530/EJE-20-0577
    1. Baran D, Hutchinson TA (1984) The outcome of hyponatremia in a general hospital population. Clin Nephrol 72–76
    1. Cuesta M, Garrahy A, Slattery D et al (2017) Mortality rates are lower in SIAD, than in hypervolaemic or hypovolaemic hyponatraemia: results of a prospective observational study. Clin Endocrinol (Oxf) 87(4):400–406. https://doi.org/10.1111/cen.13388 . Epub 2017 Jul 13
    1. Gill G, Huda B, Boyd A et al (2006) Characteristics and mortality of severe hyponatraemia: a hospital-based study. Clin Endocrinol (Oxf) 65(2):246–249. https://doi.org/10.1111/j.1365-2265.2006.02583.x

LinkOut - more resources