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. 2022 Feb;52(2):322-325.
doi: 10.1111/imj.15677.

Proposed empiric antibiotic therapy for prosthetic joint infections: an analysis of the Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO) cohort

Joshua S Davis  1   2   3 , Sarah Metcalf  4 , David L Paterson  5   6 , James O Robinson  7   8   9 , Benjamin Clarke  9 , Laurens Manning  9   10
Affiliations

Proposed empiric antibiotic therapy for prosthetic joint infections: an analysis of the Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO) cohort

Joshua S Davis et al. Intern Med J. 2022 Feb.

Abstract

Empiric antibiotic therapy in suspected prosthetic joint infection should cover likely pathogens while avoiding overly broad-spectrum antibiotics. We analysed individual patient data from a large prospective cohort study (Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO)) and found that causative organisms vary with the presentation type, with early post-operative infections more likely to be polymicrobial (41%) compared with late acute infections (10%). We thus propose empirical regimens tailored to the presentation type and presence or absence of sepsis.

Keywords: empirical antibiotics; prosthetic joint infection; septic arthritis.

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References

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