Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2022 Jun 15;35(1):ivac047.
doi: 10.1093/icvts/ivac047.

Pathological and clinical features of multiple cancers and lung adenocarcinoma: a multicentre study

Pietro Bertoglio  1 , Luigi Ventura  2 , Vittorio Aprile  3 , Maria Angela Cattoni  4 , Dania Nachira  5 , Filippo Lococo  5 , Maria Rodriguez Perez  6 , Francesco Guerrera  7 , Fabrizio Minervini  8 , Letizia Gnetti  9 , Alessandra Lenzini  3 , Francesca Franzi  10 , Giulia Querzoli  11 , Guido Rindi  12 , Salvatore Bellafiore  13 , Federico Femia  7 , Giuseppe Salvatore Bogina  11 , Diana Bacchin  3 , Peter Kestenholz  8 , Enrico Ruffini  7 , Massimiliano Paci  14 , Stefano Margaritora  5 , Andrea Selenito Imperatori  4 , Marco Lucchi  3 , Luca Ampollini  2 , Alberto Claudio Terzi  15
Affiliations
Multicenter Study

Pathological and clinical features of multiple cancers and lung adenocarcinoma: a multicentre study

Pietro Bertoglio et al. Interact Cardiovasc Thorac Surg. .

Abstract

Objectives: Lung cancer is increasingly diagnosed as a second cancer. Our goal was to analyse the characteristics and outcomes of early-stage resected lung adenocarcinomas in patients with previous cancers (PC) and correlations with adenocarcinoma subtypes.

Methods: We retrospectively reviewed data of patients radically operated on for stage I-II lung adenocarcinoma in 9 thoracic surgery departments between 2014 and 2017. Overall survival (OS) and time to disease relapse were evaluated between subgroups.

Results: We included 700 consecutive patients. PC were present in 260 (37.1%). Breast adenocarcinoma, lung cancer and prostate cancer were the most frequent (21.5%, 11.5% and 11.2%, respectively). No significant differences in OS were observed between the PC and non-PC groups (P = 0.378), with 31 and 75 deaths, respectively. Patients with PC had smaller tumours and were more likely to receive sublobar resection and to be operated on with a minimally invasive approach. Previous gastric cancer (P = 0.042) and synchronous PC (when diagnosed up to 6 months before lung adenocarcinoma; P = 0.044) were related, with a worse OS. Colon and breast adenocarcinomas and melanomas were significantly related to a lower incidence of high grade (solid or micropapillary, P = 0.0039, P = 0.005 and P = 0.028 respectively), whereas patients affected by a previous lymphoma had a higher incidence of a micropapillary pattern (P = 0.008).

Conclusions: In patients with PC, we found smaller tumours more frequently treated with minimally invasive techniques and sublobar resection, probably due to a more careful follow-up. The impact on survival is not uniform and predictable; however, breast and colon cancers and melanoma showed a lower incidence of solid or micropapillary patterns whereas patients with lymphomas had a higher incidence of a micropapillary pattern.

Keywords: Adenocarcinoma subtype; Lung adenocarcinoma; Lung cancer; Multiple cancers; Thoracic surgery.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:
Overall survival of patients with and without previous cancers affected by lung adenocarcinoma.
Figure 2:
Figure 2:
Overall survival of patients with synchronous or metachronous multiple cancers.
None
See this image and copyright information in PMC

References

    1. Zhang R, Chen C, Dong X, Shen S, Lai L, He J. et al. Independent validation of early-stage NSCLC prognostic scores incorporating epigenetic and transcriptional biomarkers with gene-gene interactions and main effects. Chest 2020;158:808–19. - PMC - PubMed
    1. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y. et al. International association for the study of lung cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011;6:244–85. - PMC - PubMed
    1. Bertoglio P, Querzoli G, Ventura L, Aprile V, Cattoni MA, Nachira D. et al. Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database. J Surg Oncol 2021;123:560–9. - PubMed
    1. Ueno M, Muto T, Oya M, Ota H, Azekura K, Yamaguchi T.. Multiple primary cancer: an experience at the Cancer Institute Hospital with special reference to colorectal cancer. Int J Clin Oncol 2003;8:162–7. - PubMed
    1. Coyte A, Morrison DS, McLoone P.. Second primary cancer risk - the impact of applying different definitions of multiple primaries: results from a retrospective population-based cancer registry study. BMC Cancer 2014;14:272. - PMC - PubMed

Publication types