Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar;24(3):312-319.
doi: 10.1111/jch.14407. Epub 2022 Feb 21.

Evaluation of left ventricular function by treadmill exercise stress echocardiography combined with layer-specific strain technique in essential hypertension patients

Zhang Qingfeng  1 , Wang Yi  1 , Li Wenhua  1 , Zhang Hongmei  1 , Ding Geqi  1 , Liu Xuebing  1 , Li Chunmei  1 , Deng Yan  1 , Yin Lixue  1
Affiliations

Evaluation of left ventricular function by treadmill exercise stress echocardiography combined with layer-specific strain technique in essential hypertension patients

Zhang Qingfeng et al. J Clin Hypertens (Greenwich). 2022 Mar.

Abstract

The purpose of this study was to evaluate the diagnostic utility of treadmill exercise stress echocardiography (TESE) combined with left ventricular (LV) layer-specific strain (LSS) in subclinical myocardial and reserve function of hypertensive patients. A total of 55 hypertensive patients and 51 controls were evaluated during rest and exercise. Two-dimensional speckle tracking (2DST) and LSS technique was used to measure longitudinal and circumferential strains at rest and peak exercise, strain difference characteristics were then evaluated. Compared to the control subjects, both longitudinal and circumferential LSS showed different degrees of reduction in hypertensive group, which was more pronounced at peak exercise. The global longitudinal endocardium strain (GLSendo) at rest was 24.4% ± 1.5% in the control group versus 20.4% ± 2.3% in the hypertensive group, while the difference was more obvious at peak state (control vs. hypertensive group, 30.8% ± 2.8% and 22.8% ± 2.9%, respectively). In particular, endocardial strain under exercise can be used as a sensitive indicator where the LV contractile reserve (CR) function of the three layers are all impaired. TESE combined with LSS might increase diagnostic accuracy of myocardial performance in hypertension patients.

Keywords: hypertension; layer-specific strain; myocardial function; treadmill exercise stress echocardiography.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Variation characteristics of longitudinal layer‐specific strain (LLSS) at rest and peak state in hypertensive group. ＊Indicating LLSS value of different layers were significantly increased (p < .05) at peak state
FIGURE 2
FIGURE 2
Variation characteristics of circumferential layer‐specific strain (CLSS) at rest and peak state in hypertensive group. ＊Indicating CLSS value of epicardial layer was significantly increased (p < .05) at peak state
See this image and copyright information in PMC

References

    1. Harry EH, livia NG, an Y, et al. Hypertension as a road to treatment of heart failure with preserved ejection fraction. Curr Hypertens Rep. 2020;3(10):82‐84. - PubMed
    1. Yogesh N Z R, Barry A B. Hypertension and heart failure: insights from exercise stress testing. Eur J Heart Fail. 2020;22(3):469‐471. - PubMed
    1. Adamu U, Schmitz F, Becker M, Kelm M, Hoffmann R. Advanced speckle tracking echocardiography allowing a three myocardial layer‐specific analysis of deformation parameters. Eur J Echocardiogr. 2009(2):303‐308. - PubMed
    1. Kai O H, Andreas J, Roman L. Speckle‐tracking and tissue‐doppler stress echocardiography in arterial hypertension: a sensitive tool for detection of subclinical LV impairment. Biomed Res Int. 2014;10(15):1‐9. - PMC - PubMed
    1. Trivedi SJ, Altman M, Stanton T, Thomas L. Echocardiographic strain in clinical practice. Heart Lung Circ. 2019;28(9):1320‐1330. - PubMed

Publication types