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. 2022 Feb;10(2):e004403.
doi: 10.1136/jitc-2021-004403.

Immunostimulatory effects of radioimmunotherapy

Julie Constanzo  1 , Lorenzo Galluzzi  2   3   4 , Jean-Pierre Pouget  5
Affiliations

Immunostimulatory effects of radioimmunotherapy

Julie Constanzo et al. J Immunother Cancer. 2022 Feb.

Abstract

Radiation therapy (RT) is known for its ability to kill cancer cells in an immunogenic manner. Recent preclinical data demonstrate that targeted alpha-particle therapy shares with RT the capacity to elicit immunostimulatory effects, standing out as a promising strategy to circumvent immune checkpoint inhibitor resistance in immunologically 'cold' tumors.

Keywords: adaptive immunity; immunotherapy; interferon inducers; radioimmunotherapy.

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Conflict of interest statement

Competing interests: LG has been holding research contracts with Lytix Biopharma and Phosplatin, and has received consulting/advisory honoraria from Boehringer Ingelheim, AstraZeneca, OmniSEQ, Onxeo, The Longevity Labs, Inzen, and the Luke Heller TECPR2 Foundation. All other authors have no conflicts to declare.

Figures

Figure 1
Figure 1
Immunostimulation by TAT. Immunologically cold tumors exhibiting robust infiltration by regulatory T (TREG) cells and M2-like tumor-associated macrophages (TAMs), but limited amounts of mature dendritic cells (DCs) and effector T (TEFF) cells, are generally insensitive to immune checkpoin inhibitors (ICIs). At least in preclinical tumor models, targeted alpha-particle therapy (TAT) has been successfully harnessed to inflame the microenvironment of immunologically cold tumors in support of restored ICI sensitivity, pointing to TAT as to a promising combinatorial partner for ICI-based immunotherapy in the clinical setting. DAMP, damage-associated molecular pattern.
See this image and copyright information in PMC

References

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