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. 2022 Dec 31;18(1):2027714.
doi: 10.1080/21645515.2022.2027714. Epub 2022 Feb 22.

Immunogenicity and safety of human diploid cell vaccine (HDCV) vs. purified Vero cell vaccine (PVRV) vs. purified chick embryo cell vaccine (PCECV) used in post-exposure prophylaxis: a systematic review and meta-analysis

Shi-Yuan Wang  1 , Jin-Fang Sun  1 , Pei Liu  1 , Li Luo  1 , Jing-Xin Li  2 , Feng-Cai Zhu  1   2   3 , Xu-Xiang Shen  1 , Fan-Yue Meng  2
Affiliations

Immunogenicity and safety of human diploid cell vaccine (HDCV) vs. purified Vero cell vaccine (PVRV) vs. purified chick embryo cell vaccine (PCECV) used in post-exposure prophylaxis: a systematic review and meta-analysis

Shi-Yuan Wang et al. Hum Vaccin Immunother. .

Abstract

This study comprehensively evaluated and compared three human rabies vaccines. Seven electronic databases were systematically searched. The Cochrane Handbook v5.1.0 was used to assess the risk of bias. A random-effects model was used to combine individual rates, and network meta-analysis was used for pairwise comparisons. Twenty-seven articles were included, with a total of 18,630 participants. The pooled incidence of the total adverse reaction to HDCV was significantly lower than that of PCECV. HDCV administration resulted in a lower incidence of local pain, fever, and weakness than purified Vero cell vaccine. HDCV caused a lower incidence of local pain and fever than PCECV. No significant difference was observed in terms of the seroconversion rate on day 7 or the rabies virus-neutralizing antibody titer on day 14. HDCV demonstrated superiority in terms of safety compared with the other two rabies vaccines, while the same was not observed in terms of immunogenicity.

Keywords: Rabies vaccines; adverse reaction; immunogenicity; meta-analysis; post-exposure prophylaxis.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Flowchart of literature selection.
Figure 2.
Figure 2.
Quality assessment of included studies. “+” represents low risk of bias; “?” represents unclear risk of bias; “-” represents high risk of bias.
Figure 3.
Figure 3.
The pooled incidence of total ARs of HDCV, PVRV and PCECV.
Figure 4.
Figure 4.
Pooled seroconversion rates on day 7 of HDCV, PVRV and PCECV.
See this image and copyright information in PMC

References

    1. Banyard AC, McElhinney LM, Johnson N, Fooks AR.. Introduction history of rabies control by vaccination. Introduction history of rabies control by vaccination. Rev Sci Tech. 2018;37(2):305–11. doi: 10.20506/rst.37.2.2804. - DOI - PubMed
    1. Fooks AR, Cliquet F, Finke S, Freuling C, Hemachudha T, Mani RS, Müller T, Nadin-Davis S, Picard-Meyer E, Wilde H, et al. Rabies. Nat Rev Dis Primers Published 2017 Nov 30. 2017;3:17091. doi: 10.1038/nrdp.2017.91. - DOI - PubMed
    1. Hampson K, Coudeville L, Lembo T, Sambo M, Kieffer A, Attlan M, Barrat J, Blanton JD, Briggs DJ, Cleaveland S, et al. Correction: estimating the global burden of endemic canine rabies. PLoS Negl Trop Dis. 2015;9(5):e0003786. Published 2015 May 11. doi: 10.1371/journal.pntd.0003786. - DOI - PMC - PubMed
    1. World Health Organization . WHO expert consultation on rabies: third report. World Health Organization; 2018. [accessed 2021 Dec 1]‎. https://apps.who.int/iris/handle/10665/272364.
    1. Li T, Wang X, Cheng H. Meta-analysis of immunogenicity and safety of human rabies vaccination under Zagreb and Essen regimens. J Comp Eff Res. 2020;9(7):459–68. doi: 10.2217/cer-2019-0202. - DOI - PubMed

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