Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Feb 22;194(7):E252-E256.
doi: 10.1503/cmaj.211856.

Possible association between rhabdomyolysis and mRNA SARS-CoV-2 vaccination in a patient with RYR1 gene mutation

Brittany Salter  1 , Matthew Jessome  2 , Mark Tarnopolsky  2 , Haroon Yousuf  2
Affiliations
Case Reports

Possible association between rhabdomyolysis and mRNA SARS-CoV-2 vaccination in a patient with RYR1 gene mutation

Brittany Salter et al. CMAJ. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests: Mark Tarnopolsky reports speaker fees from the American College of Sports Medicine and Haroon Yousuf reports a teaching honorarium from Touchstone Institute, outside the submitted work. No other competing interests were declared.

Figures

Figure 1:
Figure 1:
Magnetic resonance imaging (MRI) scans of the left thigh of a 30-year-old woman with rhabdomyolysis. (A) A T1-weighted MRI scan showed extensive fatty replacement (arrow) and edema in thigh musculature. (B) A T2-weighted MRI scan showed heterogeneous, diffuse hyper-intense areas (arrow), with extensive edema affecting the tensor fascia latae, biceps femoris and vastus lateralis muscles.
Figure 2:
Figure 2:
Change in creatine kinase levels from time of hospital admission to discharge. The peak level was at 586 647 U/L on day 4 of admission. Arrow points to the day that oral dantrolene was initiated.
See this image and copyright information in PMC

Comment in

References

    1. Zutt R, van der Kooi AJ, Linthorst GE, et al. . Rhabdomyolysis: review of the literature. Neuromuscul Disord 2014;24:651–9. - PubMed
    1. LiverTox: Clinical and research information on drug-induced liver injury. In: Dantrolene. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012; updated 2017 Jan. 30. Available: https://www.ncbi.nlm.nih.gov/books/NBK548144/ (accessed 2021 Jan. 7). - PubMed
    1. Kateon H. Differentiating serotonin syndrome and neuroleptic malignant syndrome. Ment Health Clin 2013;3:129–33.
    1. Haroun MW, Dieiev V, Kang J, et al. . Rhabdomyolysis in COVID-19 patients: a retrospective observational study. Cureus 2021;13:e12552. - PMC - PubMed
    1. Vaccine Adverse Event Reporting System. Atlanta: Centers for Disease Control and Prevention; Silver Spring (MD): US Food and Drug Administration. Available: https://www.cdc.gov/vaccinesafety/ensuringsafety/monitoring/vaers/index.... (accessed 2021 Jan. 14).

Publication types