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Review
. 2022 May;22(5):259-279.
doi: 10.1038/s41568-022-00441-w. Epub 2022 Feb 22.

CRISPR in cancer biology and therapy

Alyna Katti #  1   2 , Bianca J Diaz #  1   2 , Christina M Caragine #  3   4 , Neville E Sanjana  5   6 , Lukas E Dow  7   8
Affiliations
Review

CRISPR in cancer biology and therapy

Alyna Katti et al. Nat Rev Cancer. 2022 May.

Abstract

Over the past decade, CRISPR has become as much a verb as it is an acronym, transforming biomedical research and providing entirely new approaches for dissecting all facets of cell biology. In cancer research, CRISPR and related tools have offered a window into previously intractable problems in our understanding of cancer genetics, the noncoding genome and tumour heterogeneity, and provided new insights into therapeutic vulnerabilities. Here, we review the progress made in the development of CRISPR systems as a tool to study cancer, and the emerging adaptation of these technologies to improve diagnosis and treatment.

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