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. 2022;55(11):1133-1137.
doi: 10.1007/s11094-022-02548-8. Epub 2022 Feb 11.

Bioavailability and Safety of Dihydroquercetin (Review)

S V Orlova  1 , V V Tatarinov  2 , E A Nikitina  1 , A V Sheremeta  1 , V A Ivlev  1 , V G Vasil'ev  1 , K V Paliy  1 , S V Goryainov  1
Affiliations

Bioavailability and Safety of Dihydroquercetin (Review)

S V Orlova et al. Pharm Chem J. 2022.

Abstract

Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used for treating Middle East respiratory syndrome coronavirus (MERS-CoV) infection and is currently considered a potential regulator of oxidative stress as part of COVID-19 multipurpose therapy. DHQ has a high safety profile but low bioavailability that limits its use. Innovative techniques (liposomization, crystal engineering, etc.) can be used to increase its bioavailability.

Keywords: SARS-CoV-2; bioavailability; dihydroquercetin; safety; toxicity.

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