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. 2022 Apr;19(4):e202200028.
doi: 10.1002/cbdv.202200028. Epub 2022 Mar 9.

Acremocholone, an Anti-Vibrio Steroid from the Marine Mesophotic Zone Ciocalypta Sponge-Associated Fungus Acremonium sp. NBUF150

Yun-Ping Feng  1 , Hong-Kun Wang  1 , Jia-Ling Wu  1 , Peng Shao  2 , Wen-Li Zhou  2 , Qi-Liang Lai  3 , Hou-Wen Lin  4 , C Benjamin Naman  1 , Ting-Ting Wang  1 , Shan He  1   5
Affiliations

Acremocholone, an Anti-Vibrio Steroid from the Marine Mesophotic Zone Ciocalypta Sponge-Associated Fungus Acremonium sp. NBUF150

Yun-Ping Feng et al. Chem Biodivers. 2022 Apr.

Abstract

Mesophotic coral ecosystems (MCEs) represent an underexplored source of intriguing natural products. Efforts to discover bioactive metabolites from sponge-associated fungi in MCEs identified a new steroid, acremocholone (1) and its three known analogs (2-4), from Acremonium sp. NBUF150. The Acremonium sp. NBUF150 was isolated from a Ciocalypta sponge located 70 m deep within the South China Sea. The planar structures and absolute configuration of 1-4 were determined from NMR-derived spectroscopic data, HR-ESI-MS, and X-ray crystallography. Compound 1 exhibited antimicrobial inhibition against Vibrio scophthalmi, V. shilonii and V. brasiliensis at minimum inhibitory concentrations of 8 μg/mL; compound 2 inhibited V. shilonii and V. brasiliensis at 8 and 32 μg/mL, respectively, and compound 4 inhibited growth of V. brasiliensis at 16 μg/mL. Sponge associated fungi from MCEs represent a promising resource of anti-Vibrio drug leads for aquaculture use.

Keywords: Acremonium; anti-Vibrio; mesophotic coral ecosystems; sponge-associated fungi; steroid.

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