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. 2022 Apr 1;158(4):451-452.
doi: 10.1001/jamadermatol.2022.0015.

The ñ Sign: A Visual Clue for the Histopathologic Diagnosis of Psoriasis

Ángel Fernández Camporro  1 , Mónica Roncero-Riesco  2 , Leonor Revelles-Peñas  2 , David Revilla Nebreda  2 , Ángela Estenaga  3 , Javier Díaz de la Pinta  4 , Ángel Santos-Briz Terrón  4
Affiliations

The ñ Sign: A Visual Clue for the Histopathologic Diagnosis of Psoriasis

Ángel Fernández Camporro et al. JAMA Dermatol. .

Abstract

This qualitative study describes a visual clue for the diagnosis of psoriasis, in which the sum of the fragmentation and separation of the laminar parakeratotic stratum corneum and hyperplasia with regular elongation of the rete ridges resembles the letter ñ on histopathologic biopsy specimens.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure.
Figure.. Photomicrograph of a Psoriatic Lesion Biopsy Specimen With the ñ Sign
The ñ sign in this specimen is formed by the sum of the fragmentation and separation of the laminar parakeratotic stratum corneum (top) and hyperplasia with regular elongation of the rete ridges (bottom) (hematoxylin-eosin, original magnification ×200).
See this image and copyright information in PMC

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