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Comment
. 2022 Mar 1;71(3):376-378.
doi: 10.2337/dbi21-0035.

Imeglimin to the Rescue: Enhanced CHOP/GADD34/eIF2α Signaling Axis Promotes β-Cell Survival

Seokwon Jo, Emilyn U Alejandro
Comment

Imeglimin to the Rescue: Enhanced CHOP/GADD34/eIF2α Signaling Axis Promotes β-Cell Survival

Seokwon Jo et al. Diabetes. .
No abstract available

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Figures

Figure 1
Figure 1
ER stress and CHOP level in β-cell survival by imeglimin. In response to insulin demand, UPR is associated with induction of β-cell proliferation and β-cell mass expansion. However, under chronic or overt ER stress conditions (e.g., Tg) with increased levels of ER stress, CHOP is associated with cell death. Uniquely, imeglimin treatment protects β-cell apoptosis from ER stress (e.g., Tg) by promoting further increase in expression of CHOP and GADD34, reversing eIF2α phosphorylation and, thereby, global translation.
See this image and copyright information in PMC

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