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. 2022 Jan-Mar;17(1):66-69.
doi: 10.4103/atm.atm_520_21. Epub 2022 Jan 14.

A COVID-19 family cluster with retinitis pigmentosa and hypogammaglobulinemia

Abeer N Alshukairi  1   2 , Yasser A Aldabbagh  1   3 , Najla M Sayes  1 , Manal M Al Gethamy  4 , Mohammed G Alghamdi  5 , Zuhair A Rahbeeni  6 , Ashraf Dada  2   7
Affiliations

A COVID-19 family cluster with retinitis pigmentosa and hypogammaglobulinemia

Abeer N Alshukairi et al. Ann Thorac Med. 2022 Jan-Mar.

Abstract

Hypogammaglobulinemia is a heterogeneous group of innate and acquired antibody deficiency with variable disease severity, recurrent pneumonia, and bronchiectasis. The outcome of COVID in patients with hypogammaglobulinemia is variable depending on age, comorbidities, type of immunodeficiency, and use of immunoglobulins. We report the favorable outcome of two family members diagnosed with DNAJC17-related retinitis pigmentosa and hypogammaglobulinemia syndrome and infected with SARS-CoV-2 following contact with their mother who had COVID-19. We describe the different immune dysfunction in these patients and their impact on the course and management of SARS-CoV-2 infection.

Keywords: COVID-19; hypogammaglobulinemia; outcome; retinitis pigmentosa.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Chest Xray showed radiological progression of case 1
Figure 2
Figure 2
Chest Xray showed radiological progression of case 2
See this image and copyright information in PMC

References

    1. Cinetto F, Scarpa R, Rattazzi M, Agostini C. The broad spectrum of lung diseases in primary antibody deficiencies. Eur Respir Rev. 2018;27:180019. - PMC - PubMed
    1. Geng J, Yu X, Bao H, Feng Z, Yuan X, Zhang J, et al. Chronic diseases as a predictor for severity and mortality of COVID-19: A systematic review with cumulative meta-analysis. Front Med (Lausanne) 2021;8:588013. - PMC - PubMed
    1. Cohen B, Rubinstein R, Gans MD, Deng L, Rubinstein A, Eisenberg R. COVID-19 infection in 10 common variable immunodeficiency patients in New York City. J Allergy Clin Immunol Pract. 2021;9:504–7e1. - PMC - PubMed
    1. Shields AM, Burns SO, Savic S. UK PIN COVID-19 Consortium. COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience. J Allergy Clin Immunol. 2021;147:870–5e1. - PMC - PubMed
    1. Starr JC, Brasher GW, Dominguez J, Rao A. Retinitis pigmentosa and hypogammaglobulinemia. South Med J. 2006;99:989–91. - PubMed

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