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Review
. 2022 May;24(5):603-610.
doi: 10.1007/s11912-022-01219-x. Epub 2022 Feb 24.

Clinicopathological Review of Micropapillary Urothelial Carcinoma

Deepika Kumar  1 , Adebowale J Adeniran  2
Affiliations
Review

Clinicopathological Review of Micropapillary Urothelial Carcinoma

Deepika Kumar et al. Curr Oncol Rep. 2022 May.

Abstract

Purpose of review: This review will discuss micropapillary urothelial carcinoma with respect to biology, histopathologic characteristics, genetic and molecular features, diagnosis, clinical management, and future directions of research.

Recent findings: Recent consensus opinion study showed only moderate interobserver reproducibility in the diagnostic criteria. The most reproducible criteria with the highest consensus were multiple nests in the same lacunar spaces. There are recent reports of high rates of intratumoral heterogeneity of ERBB2 amplification within tumor containing both micropapillary and classic urothelial components. Micropapillary urothelial carcinoma is a well-documented highly aggressive variant of urothelial carcinoma with proven worse outcomes. Accurate recognition and reporting of this pattern is critical for optimal management. Newer therapeutic strategies related to the molecular and genetic findings seen in MPUC remain to be explored further.

Keywords: Aggressive variant; Bladder; Lacunae; Management; Micropapillary; Morphology; Prognosis; Urothelial carcinoma.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
    1. Teoh JY, Huang J, Ko WY, et al. Global trends of bladder cancer incidence and mortality, and their associations with tobacco use and gross domestic product per capita. Eur Urol. 2020;78(6):893–906. - DOI
    1. Wigner P, Bijak M, Saluk-Bijak J. The green anti-cancer weapon The Role of Natural Compounds in Bladder Cancer Treatment. Int J Mol Sci. 2021;22(15):7787. - DOI
    1. • Lobo N, Shariat SF, Guo CC, et al. What is the significance of variant histology in urothelial carcinoma? Eur Urol Focus. 2020;6(4):653–63. This paper provides an overview of the diagnostic, therapeutic, and prognostic significance of micropapillary urothelial carcinoma. - DOI
    1. Antoni S, Ferlay J, Soerjomataram I, et al. Bladder cancer incidence and mortality: a global overview and recent trends. Eur Urol. 2017;71(1):96–108. - DOI
    1. Moch H, Humphrey PA, Ulbright TM et al. Eds. WHO classification of tumors of the urinary system and male genital organs. Lyon, France: International Agency for Research on Cancer, 2016

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