Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2022 Apr;46(4):531-540.
doi: 10.1111/aor.14200. Epub 2022 Feb 24.

Jose Delgado: A controversial trailblazer in neuromodulation

Nicholas D Lorusso  1 , Uma R Mohan  2 , Joshua Jacobs  2   3
Affiliations
Editorial

Jose Delgado: A controversial trailblazer in neuromodulation

Nicholas D Lorusso et al. Artif Organs. 2022 Apr.

Abstract

Dr. Jose Delgado performed audacious demonstrations utilizing brain stimulation to instantly change behavior in animals. These feats spark ethical debates to this day. However, behind his controversial career is an important legacy of neurological discoveries and technological innovation. Delgado pioneered techniques in causally manipulating brain patterns and behavior with electrical stimulation and developed innovative, closed-loop neural devices. His inventive devices and techniques were ahead of his time and remain relevant to the field of neuromodulation today.

PubMed Disclaimer

References

REFERENCES

    1. Scarf M. Brain researcher José Delgado asks' what kind of humans would we like to construct? New York Times. 1970;153-70.
    1. Horgan J. The forgotten era of brain chips. Sci Am. 2005;293(4):66-73.
    1. Borchers S, Himmelback M, Logothetis NK, Karanath H. Direct electrical stimulation of the human cortex-the gold standard for mapping brain functions? Nat Rev Neurosci. 2012;13(1):63-70.
    1. Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, et al. Deep brain stimulation surgery for treatment resistant depression. Neuron. 2005;45:651-60.
    1. Ramon y Cajal S. Histologie du systeme nerveux de l’homme & des vert´ebr´es: Cervelet, cerveau moyen, r´etine, couche optique, corps stri´e, ´ecorce c´er´ebrale g´en´erale & r´egionale, grand sympathique. Vol 2. Paris, France: A. Maloine; 1911.

Publication types

LinkOut - more resources