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. 2022;41(11):1099-1108.
doi: 10.1080/15257770.2022.2032738. Epub 2022 Feb 24.

Variability in CD39 and CD73 protein levels in uveal melanoma patients

Olivier Harou  1 , Emeline Cros-Perrial  2 , Eudeline Alix  3 , Evelyne Callet-Bauchu  3 , Charlotte Bertheau  1 , Charles Dumontet  2   3 , Mojgan Devouassoux-Shisheboran  1   4 , Lars Petter Jordheim  3
Affiliations

Variability in CD39 and CD73 protein levels in uveal melanoma patients

Olivier Harou et al. Nucleosides Nucleotides Nucleic Acids. 2022.

Abstract

Extracellular adenosine is produced from ATP by CD39 and CD73, and can modulate tumor development by acting on cancer cells or immune cells. Adenosine metabolism has been poorly studied in uveal melanoma. We studied the protein levels of CD39 and CD73 in a small, well described cohort of patients with uveal melanoma. Our results show a high variability in the levels of the two proteins, both in positivity and in intensity. Our results suggest that similar studies on larger cohorts could determine the clinical value and the druggability of these enzymes in the given clinical setting.Supplemental data for this article is available online at http://dx.doi.org/10.1080/15257770.2022.2032738.

Keywords: CD39; CD73; immunohistochemistry; uveal melanoma.

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